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Browsing Systems Biology Ireland by Date published
Now showing items 1-20 of 153
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(Springer, 2008-06)Sensitivity Analysis (SA) provides techniques which can be used to identify the parameters which have the greatest influence on the results obtained from a model. Classical SA methods apply to deterministic simulations of ...
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(The Royal Society of Chemistry, 2009)Stem cells hold great promise as a means of treating otherwise incurable, degenerative diseases due to their ability both to self-renew and differentiate. However, stem cell damage can also play a role in the disease with ...
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(Springer (Biomed Central Ltd.), 2009)Background: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell signalling pathway that relays the signal for a cell to proliferate from the plasma ...
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(Elsevier, 2009-03)The Src homology 2 (SH2) and collagen domain protein Shc plays a pivotal role in signaling via tyrosine kinase receptors, including epidermal growth factor receptor (EGFR). Shc binding to phospho-tyrosine residues on ...
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(American Society for Microbiology, 2009-03-18)BK virus (BKV) causes persistent and asymptomatic infections in most humans and is the etiologic agent of polyomavirus-associated nephropathy (PVAN) and other pathologies. Unfortunately, there are no animal models with ...
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(Public Library of Science, 2009-03-20)The temporal and stationary behavior of protein modification cascades has been extensively studied, yet little is known about the spatial aspects of signal propagation. We have previously shown that the spatial separation ...
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(Oxford University Press, 2009-03-21)Repair of single-stranded DNA breaks before DNA replication is critical in maintaining genomic stability; however, how cells deal with these lesions during S phase is not clear. Using combined approaches of proteomics and ...
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(Nature Publishing Group, 2009-04-07)
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(Nature Publishing Group, 2009-05-15)Cells can adapt to hypoxia through the activation of hypoxia-inducible factor-1 (HIF-1), which in turn regulates the expression of hypoxia-responsive genes. Defects in hypoxic signaling have been suggested to underlie the ...
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(Elsevier, 2009-08)Although endocytosis has traditionally been understood as a signal attenuation mechanism, an emerging view considers endocytosis as an integral part of signal propagation and processing. On the short time scale, trafficking ...
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(Wiley Blackwell (Blackwell Publishing), 2009-08)Src-family kinases (SFKs) play a pivotal role in growth factor signaling, mitosis, cell motility and invasiveness. In their basal state, SFKs maintain a closed autoinhibited conformation, where the Src homology 2 domain ...
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(Oxford University Press, 2009-08-11)The human single-stranded DNA-binding protein, replication protein A (RPA), is regulated by the N-terminal phosphorylation of its 32-kDa subunit, RPA2. RPA2 is hyperphosphorylated in response to various DNA-damaging agents ...
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(American Society for Microbiology, 2009-10-12)As well as providing a structural framework, the actin cytoskeleton plays integral roles in cell death, survival, and proliferation. The disruption of the actin cytoskeleton results in the activation of the c-Jun N-terminal ...
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(Elsevier, 2009-12)Emerging evidence indicates that complex spatial gradients and (micro)domains of signalling activities arise from distinct cellular localization of opposing enzymes, such as a kinase and phosphatase, in signal transduction ...
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(American Physical Society, 2009-12)We study the effect of advection on the aggregation and pattern formation in chemotactic systems described by Keller-Segel-type models. The evolution of small perturbations is studied analytically in the linear regime ...
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Theoretical and experimental analysis links isoform- specific ERK signalling to cell fate decisions (Nature Publishing Group, 2009-12-22)Cell fate decisions are regulated by the coordinated activation of signalling pathways such as the extracellular signal-regulated kinase (ERK) cascade, but contributions of individual kinase isoforms are mostly unknown. ...
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(Springer (Biomed Central Ltd.), 2010)Mesenchymal stem cells have a natural tropism for tumours and their metastases, and are also considered immunoprivileged. This remarkable combination of properties has formed the basis for many studies investigating their ...
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(Springer (Biomed Central Ltd.), 2010)Background: The importance of appropriate normalization controls in quantitative real-time polymerase chain reaction (qPCR) experiments has become more apparent as the number of biological studies using this methodology ...
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(The Royal Society of Chemistry, 2010)Quenched-phosphorescence oxygen (O2) sensing technique allows non-invasive, real-time monitoring of both intra- and extracellular O2 concentration in respiring samples. Using this technique we investigated O2 gradients in ...
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(Springer (Biomed Central Ltd.), 2010)Background: Electronic clinical decision support (CDS) is increasingly establishing its role in evidence-based clinical practice. Considerable evidence supports its enhancement of efficiency in e-Prescribing, but some ...
Now showing items 1-20 of 153