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Search Results for Collection: Systems Biology Ireland
Now showing items 1-10 of 10
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(Public Library of Science, 2011-11-16)Numerous unimolecular, genetically-encoded Förster Resonance Energy Transfer (FRET) probes for monitoring biochemical activities in live cells have been developed over the past decade. As these probes allow for collection ...
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(The Royal Society of Chemistry, 2012)The abundance of a particular protein varies both over time within a single mammalian cell and between cells of a genetically identical population. Here, we investigate the properties of such noisy protein expression in ...
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(National Academy of Sciences, 2013-10)Hypoxia is a prominent feature of chronically inflamed tissues. Oxygen-sensing hydroxylases control transcriptional adaptation to hypoxia through the regulation of hypoxia-inducible factor (HIF) and nuclear factor κB ...
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(Public Library of Science, 2014-09-18)Cilia are highly conserved microtubule-based structures that perform a variety of sensory and motility functions during development and adult homeostasis. In humans, defects specifically affecting motile cilia lead to ...
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(American Chemical Society, 2014-06-06)Epithelial to mesenchymal transition (EMT) is a fundamental cell differentiation/dedifferentiation process which is associated with dramatic morphological changes. Formerly polarized and immobile epithelial cells which ...
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(MDPI, 2014-04-16)With the advent of the '-omics' era, biological research has shifted from functionally analyzing single proteins to understanding how entire protein networks connect and adapt to environmental cues. Frequently, pathological ...
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(The Royal Society, 2014-06-25)We show theoretically and experimentally a mechanism behind the emergence of wide or bimodal protein distributions in biochemical networks with nonlinear input–output characteristics (the dose–response curve) and variability ...
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(American Society for Biochemistry and Molecular Biology, 2015-12-11)Endothelial cells release prostacyclin (PGI2) and nitric oxide (NO) to inhibit platelet functions. PGI2 and NO effects are mediated by cyclic nucleotides, cAMP- and cGMP-dependent protein kinases (PKA, PKG), and largely ...
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(Royal Society of Chemistry, 2014-09)Multifunctional nanoparticles that actively target specific cells are promising tools for cancer diagnosis and therapy. In this article we review the synthesis and surface chemistry of Fe–Au nanorods and their characterization ...
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(Wiley, 2015-02-18)Multifunctional nanoparticles that actively target-specific tissues are studied for cancer diagnosis and treatment. Magnetically and optically active particles are of particular interest because they enable multiple imaging ...
Now showing items 1-10 of 10