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Search Results for Collection: Systems Biology Ireland
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(American Society for Microbiology, 2011-12-28)BK polyomavirus (BKV) establishes persistent, low-level, and asymptomatic infections in most humans and causes polyomavirus-associated nephropathy (PVAN) and other pathologies in some individuals. The activation of BKV ...
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(American Society for Microbiology, 2011-05-04)Small noncoding RNAs regulate a variety of cellular processes, including genomic imprinting, chromatin remodeling, replication, transcription, and translation. Here, we report small replication-regulating RNAs (srRNAs) ...
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(Taylor & Francis, 2011)To perceive an affordance is to perceive what the current layout of surfaces affords with respect to one’s body size and action capabilities (Gibson, 1979). Affordance experiments have demonstrated that the shift from one ...
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(Wiley Blackwell (John Wiley & Sons), 2011-07-04)In an effort to reduce organ replacement and enhance tissue repair, there has been a tremendous effort to create biomechanically optimized scaffolds for tissue engineering applications. In contrast, the development and ...
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(Public Library of Science, 2011-12-15)In an active, self-ubiquitinated state, the Ring1B ligase monoubiquitinates histone H2A playing a critical role in Polycomb-mediated gene silencing. Following ubiquitination by external ligases, Ring1B is targeted for ...
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(American Association for Cancer Research, 2011-04-21)A-Raf kinase can inhibit apoptosis by binding to the proapoptotic mammalian sterile 20-like kinase (MST2). This function relies on expression of hnRNP H, which ensures the correct splicing of a-raf mRNA needed to produce ...
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(Springer (Biomed Central Ltd.), 2011)Protein phosphorylation participates in the regulation of all fundamental biological processes, and protein kinases have been intensively studied. However, while the focus was on catalytic activities, accumulating evidence ...
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(Nature Publishing Group, 2011-06-30)Although successful, drug-eluting stents require significant periods of dual anti-platelet therapy with a persistent risk of late stent thrombosis due to inhibition of re-endothelialization. Endothelial regeneration is ...
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(American Society for Biochemistry and Molecular Biology, 2011-09-06)The monosaccharide, β-N-acetylglucosamine (GlcNAc), can be added to the hydroxyl group of either serines or threonines to generate an O-linked β-N-acetylglucosamine (O-GlcNAc) residue (Love, D. C., and Hanover, J. A. (2005) ...
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(Landes Bioscience, 2011-07-01)Negative feedback is an ubiquitous feature of biological networks. Recent work from Sturm and colleaguespresents experimental evidence that biological negative feedback can serve the same function as it does for engineered ...