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Search Results for Collection: Systems Biology Ireland
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Cell Cycle-Dependent Mobility of Cdc45 Determined in vivo by Fluorescence Correlation Spectroscopy (Public Library of Science, 2012-04-19)Eukaryotic DNA replication is a dynamic process requiring the co-operation of specific replication proteins. We measured the mobility of eGFP-Cdc45 by Fluorescence Correlation Spectroscopy (FCS) in vivo in asynchronous ...
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(American Society for Biochemistry and Molecular Biology, 2012-08-10)DNA polymerases (Pol) α, δ, and ϵ replicate the bulk of chromosomal DNA in eukaryotic cells, Pol ϵ being the main leading strand and Pol δ the lagging strand DNA polymerase. By applying chromatin immunoprecipitation (ChIP) ...
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NAMBU BRACKET FORMULATION OF NONLINEAR BIOCHEMICAL REACTIONS BEYOND ELEMENTARY MASS ACTION KINETICS (Informa UK (Taylor & Francis), 2012-01)We develop a Nambu bracket formulation for a wide class of nonlinear biochemical reactions by exploiting previous work that focused on elementary biochemical mass action reactions. To this end, we consider general reaction ...
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(Cambridge University Press, 2012-04-26)
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(Springer-Verlag, 2012-03-07)We study the emergence of oscillatory self-sustained behavior in a nonequilibrium Nambu system that features an exchange between different kinetical and potential energy forms. To this end, we study the Yamaleev oscillator ...
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(Elsevier, 2012-09)Once damaged, cardiac muscle has little intrinsic repair capability due to the poor regeneration potential of remaining cardiomyocytes. One method of overcoming this issue is to deliver functional cells to the injured ...
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(Nature Publishing Group, 2012-08-27)Bcr-Abl is the major cause and pathogenetic principle of chronic myeloid leukemia (CML). Bcr-Abl results from a chromosomal translocation that fuses the bcr and abl genes, thereby generating a constitutively active tyrosine ...
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(Cognizant Communication Corp, 2012-06-01)Tissue necrosis resulting from critical limb ischemia (CLI) leads to amputation in a significant number of patients. Autologous cell therapy using angiogenic cells such as endothelial progenitor cells (EPCs) holds promise ...
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(European Cells & Materials Ltd, 2012-04-21)Multipotent mesenchymal stem cells (MSCs) have been suggested as a suitable cell source for cell-based treatments for diseases such as osteoarthritis due to their ability to differentiate towards chondrogenic and osteogenic ...
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(The Company of Biologists, 2012-02-10)Upregulation of the extracellular signal-regulated kinase (ERK) pathway has been shown to contribute to tumour invasion and progression. Because the two predominant ERK isoforms (ERK1 and ERK2, also known as MAPK3 and ...