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Search Results for Collection: Systems Biology Ireland
Now showing items 1-4 of 4
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(The Company of Biologists, 2013-02-06)Activation of the hypoxia-inducible factor (HIF) pathway is a critical step in the transcriptional response to hypoxia. Although many of the key proteins involved have been characterised, the dynamics of their interactions ...
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(National Academy of Sciences, 2013-10)Hypoxia is a prominent feature of chronically inflamed tissues. Oxygen-sensing hydroxylases control transcriptional adaptation to hypoxia through the regulation of hypoxia-inducible factor (HIF) and nuclear factor κB ...
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(Elsevier - WB Saunders, 2010-12)Background & Aims: Hypoxia inducible factor (HIF) prolyl hydroxylase inhibitors are protective in mouse models of inflammatory bowel disease (IBD). Here, we investigated the therapeutic target(s) and mechanism(s) involved. ...
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(Walter de Gruyter GmbH, 2013-01-01)Hypoxia is associated with a diverse range of physiological and pathophysiological processes, including development, wound healing, inflammation, vascular disease and cancer. The requirement that eukaryotic cells have for ...
Now showing items 1-4 of 4