Synthesis of a conformationally constrained delta-amino acid building block

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dc.contributor.author O'Reilly, Elaine
dc.contributor.author Pes, Lara
dc.contributor.author Ortin, Yannick
dc.contributor.author Müller-Bunz, Helge
dc.contributor.author Paradisi, Francesca
dc.date.accessioned 2013-03-20T12:15:19Z
dc.date.available 2014-02-02T04:00:14Z
dc.date.copyright 2013, Springer en
dc.date.issued 2013-02
dc.identifier.citation Amino Acids en
dc.identifier.uri http://hdl.handle.net/10197/4196
dc.description.abstract Conformationally restricted amino acids are important components in peptidomimetics and drug design. Herein, we describe the synthesis of a novel, non-proteinogenic constrained delta amino acid containing a cyclobutane ring, cis-3(aminomethyl)cyclobutane carboxylic acid (ACCA). The synthesis of the target amino acid was achieved in seven steps, with the key reaction being a base induced intramolecular nucleophilic substitution. A small library of dipeptides was prepared through the coupling of ACCA with proteinogenic amino acids. en
dc.language.iso en en
dc.publisher Springer en
dc.rights The final publication is available at www.springerlink.com en
dc.subject Non-proteinogenic amino acid en
dc.subject Dipeptides en
dc.subject Conformational restriction en
dc.subject Cyclobutane ring en
dc.title Synthesis of a conformationally constrained delta-amino acid building block en
dc.type Journal Article en
dc.internal.authorcontactother francesca.paradisi@ucd.ie
dc.internal.availability Full text available en
dc.status Not peer reviewed en
dc.identifier.volume 44 en
dc.identifier.issue 2 en
dc.identifier.startpage 511 en
dc.identifier.endpage 518 en
dc.identifier.doi 10.1007/s00726-012-1362-3
dc.neeo.contributor O'Reilly|Elaine|aut|
dc.neeo.contributor Pes|Lara|aut|
dc.neeo.contributor Ortin|Yannick|aut|
dc.neeo.contributor Müller-Bunz|Helge|aut|
dc.neeo.contributor Paradisi|Francesca|aut|
dc.description.admin Author has checked copyright en
dc.description.admin AMS. The delta sign is in the article title rather that the word delta. Not sure where to find this. en
dc.internal.rmsid 286432296
dc.date.updated 2013-01-21T12:12:23Z


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