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Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest
Date Issued
2013-08-13
Date Available
2014-08-13T03:00:07Z
Abstract
The interaction of nanoscaled materials with biological systems is currently the focus of a fast-growing area of investigation. Though many nanoparticles interact with cells without acute toxic responses, amino-modified polystyrene nanoparticles are known to induce cell death. We have found that by lowering their dose, cell death remains low for several days while, interestingly, cell cycle progression is arrested. In this scenario, nanoparticle uptake, which we have recently shown to be affected by cell cycle progression, develops differently over time due to the absence of cell division. This suggests that the same nanoparticles can trigger different pathways depending on exposure conditions and the dose accumulated.
Type of Material
Journal Article
Publisher
ACS Publications
Journal
ACS NANO
Volume
7
Issue
9
Start Page
7483
End Page
7494
Copyright (Published Version)
2013 American Chemical Society
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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Owning collection
Scopus© citations
80
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