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Genetically modified mesenchymal stem cells and their clinical potential in acute cardiovascular disease
Date Issued
2010-03-14
Date Available
2013-11-28T15:06:40Z
Abstract
Adult mesenchymal stem cells (MSCs) are non-hematopoietic cells with multi-lineage potential to differentiate into various tissues of mesodermal origin. They can be isolated from bone marrow and other tissues and have the capacity to extensively proliferate in vitro. Moreover, MSCs have also been shown to produce anti-inflammatory molecules which can modulate humoral and cellular immune responses. Considering their regenerative potential and immunoregulatory effect, MSC therapy is a promising tool in the treatment of degenerative, inflammatory, and autoimmune diseases. However, the current understanding from results of clinical trials is that MSC-therapy is safe but its therapeutic efficiency needs to be improved. In this article we will focus on options for genetic manipulation of MSCs and on current progress in adapting genetically-modified MSCs for clinical use in acute cardiovascular disease.
Other Sponsorship
SFI & HRB
Type of Material
Journal Article
Publisher
Discovery Medicine
Journal
Discovery Medicine
Volume
9
Issue
46
Start Page
219
End Page
223
Copyright (Published Version)
2010 Discovery Medicine
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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