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Regulation of oscillation dynamics in biochemical systems with dual negative feedback loops
Author(s)
Date Issued
2012-03-14
Date Available
2013-11-28T17:36:00Z
Abstract
Feedback controls are central to cellular regulation. Negative-feedback mechanisms are well known to underline oscillatory dynamics. However, the presence of multiple negative-feedback mechanisms is common in oscillatory cellular systems, raising intriguing questions of how they cooperate to regulate oscillations. In this work, we studied the dynamical properties of a set of general biochemical motifs with dual, nested negative-feedback structures. We showed analytically and then confirmed numerically that, in these motifs, each negative-feedback loop exhibits distinctly different oscillation-controlling functions. The longer, outer feedback loop was found to promote oscillations, whereas the short, inner loop suppresses and can even eliminate oscillations. We found that the position of the inner loop within the coupled motifs affects its repression strength towards oscillatory dynamics. Bifurcation analysis indicated that emergence of oscillations may be a strict parametric requirement and thus evolutionarily tricky. Investigation of the quantitative features of oscillations (i.e. frequency, amplitude and mean value) revealed that coupling negative feedback provides robust tuning of the oscillation dynamics. Finally, we demonstrated that the mitogen-activated protein kinase (MAPK) cascades also display properties seen in the general nested feedback motifs. The findings and implications in this study provide novel understanding of biochemical negative-feedback regulation in a mixed wiring context.
Other Sponsorship
Science Foundation Ireland's funding award–06/CE/B1129.
Type of Material
Journal Article
Publisher
The Royal Society
Journal
Journal of The Royal Society Interface
Volume
9
Issue
73
Start Page
1998
End Page
2010
Copyright (Published Version)
2012 The Royal Society
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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