High-content analysis for drug delivery and nanoparticle applications

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dc.contributor.author Brayden, David James
dc.contributor.author Cryan, Sally-Ann
dc.contributor.author Dawson, Kenneth A.
dc.contributor.author O'Brien, Peter J.
dc.contributor.author Simpson, Jeremy C.
dc.date.accessioned 2015-06-27T18:37:41Z
dc.date.available 2015-06-27T18:37:41Z
dc.date.copyright 2015 Elsevier en
dc.date.issued 2015-04
dc.identifier.citation Drug Discovery Today en
dc.identifier.uri http://hdl.handle.net/10197/6636
dc.description.abstract High-content analysis (HCA) provides quantitative multiparametric cellular fluorescence data. From its origins in discovery toxicology, it is now addressing fundamental questions in drug delivery. Nanoparticles (NPs), polymers, and intestinal permeation enhancers are being harnessed in drug delivery systems to modulate plasma membrane properties and the intracellular environment. Identifying comparative mechanistic cytotoxicity on sublethal events is crucial to expedite the development of such systems. NP uptake and intracellular routing pathways are also being dissected using chemical and genetic perturbations, with the potential to assess the intracellular fate of targeted and untargeted particles in vitro. As we discuss here, HCA is set to make a major impact in preclinical delivery research by elucidating the intracellular pathways of NPs and the in vitro mechanistic-based toxicology of formulation constituents. en
dc.description.sponsorship Department of Agriculture, Food and the Marine en
dc.description.sponsorship European Commission - Seventh Framework Programme (FP7) en
dc.description.sponsorship Science Foundation Ireland en
dc.language.iso en en
dc.publisher Elsevier en
dc.rights This is the author’s version of a work that was accepted for publication in Drug Discovery Today. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Drug Discovery Today (VOL#, ISSUE#, (2015)) DOI: 10.1016/j.drudis.2015.04.001 en
dc.subject Cellular toxicology en
dc.subject Drug delivery vehicles en
dc.subject Nanoparticle intracellular routing en
dc.subject Small interfering RNA (siRNA) en
dc.title High-content analysis for drug delivery and nanoparticle applications en
dc.type Journal Article en
dc.internal.authorcontactother david.brayden@ucd.ie
dc.check.info Check for published version en
dc.status Peer reviewed en
dc.check.date 2015-12-27
dc.identifier.doi 10.1016/j.drudis.2015.04.001
dc.neeo.contributor Brayden|David James|aut|
dc.neeo.contributor Cryan|Sally-Ann|aut|
dc.neeo.contributor Dawson|Kenneth A.|aut|
dc.neeo.contributor O'Brien|Peter J.|aut|
dc.neeo.contributor Simpson|Jeremy C.|aut|
dc.internal.rmsid 494662402
dc.date.updated 2015-06-04T10:59:33Z


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