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Towards Biofunctional Microneedles for Stimulus Responsive Drug Delivery
Author(s)
Date Issued
2015
Date Available
2016-08-23T12:52:28Z
Abstract
Microneedles have recently been adopted for use as a painless and safe method of transdermal therapeutic delivery through physically permeating the stratum corneum. While microneedles create pathways to introduce drugs, they can also act as conduits for biosignal sensing. Here, we explore the development of microneedles as both biosensing and drug delivery platforms. Microneedle sensors are being developed for continuous monitoring of biopotentials and bioanalytes through the use of conductive and electrochemically reactive biomaterials. The range of therapeutics being delivered through microneedle devices has diversified, while novel bioabsorbable microneedles are undergoing first-in-human clinical studies. We foresee that future microneedle platform development will focus on the incorporation of biofunctional materials, designed to deliver therapeutics in a stimulus responsive fashion. Biofunctional microneedle patches will require improved methods of attaching to and conforming to epithelial tissues in dynamic environments for longer periods of time and thus present an assortment of new design challenges. Through the evolution of biomaterial development and microneedle design, biofunctional microneedles are proposed as a next generation of stimulus responsive drug delivery systems.
Other Sponsorship
Naughton Foundation
Marie Sklodowska-Curie Individual Fellowship
Type of Material
Journal Article
Publisher
American Chemical Society
Journal
Bioconjugate chemistry
Volume
26
Issue
7
Start Page
1289
End Page
1296
Copyright (Published Version)
2015 American Chemical Society
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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Towards_Biofunctional_Microneedles_for_Stimulus_Responsive_Drug_Delivery__-_Final_Draft.pdf
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6.85 MB
Format
Owning collection
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