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Demonstration of the utility of biomarkers for dietary intake assessment; proline betaine as an example
Date Issued
2017
Date Available
2018-04-24T01:00:13Z
Abstract
Scope: There is a dearth of studies demonstrating the use of dietary biomarkers for determination of food intake. The objective of this study was to develop calibration curves for use in quantifying citrus intakes in an independent cohort. Methods and results: Participants (n=50) from the NutriTech food-intake study consumed standardized breakfasts for three consecutive days over three consecutive weeks. Orange juice intake decreased over the weeks. Urine samples were analyzed by NMR-spectroscopy and proline betaine was quantified and normalized to osmolality. Calibration curves were developed and used to predict citrus intake in an independent cohort; the Irish National Adult Nutrition Survey (NANS) (n=565). Proline betaine displayed a dose-response relationship to orange juice intake in 24h and fasting samples (p<0.001). In a test set, predicted orange juice intakes displayed excellent agreement with true intake. There were significant associations between predicted intake measured in 24h and fasting samples and true intake(r=0.710- 0.919). Citrus intakes predicted for the NANS cohort demonstrated good agreement with self-reported intake and this agreement improved following normalization to osmolality. Conclusion: The developed calibration curves successfully predicted citrus intakes in an independent cohort. Expansion of this approach to other foods will be important for the development of objective intake measurements.
Sponsorship
Department of Agriculture, Food and the Marine
European Research Council
Health Research Board
Science Foundation Ireland
Other Sponsorship
NutriTech
Type of Material
Journal Article
Publisher
Wiley
Journal
Molecular Nutrition and Food Research
Volume
61
Issue
10
Copyright (Published Version)
2017 Wiley
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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Proline_Betaine_MNF_Comments_May_UNmarked-FINAL_pdf.pdf
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526.85 KB
Format
Owning collection
Scopus© citations
57
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