Demonstration of the utility of biomarkers for dietary intake assessment; proline betaine as an example

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Show simple item record Gibbons, Helena Michielsen, Charlotte J. R. Rundle, Milena McNulty, Breige A. Nugent, Anne P. Gibney, Michael J. Brennan, Lorraine et al. 2017-05-19T11:32:15Z 2018-04-24T01:00:13Z 2017 Wiley en 2017
dc.identifier.citation Molecular Nutrition and Food Research en
dc.description.abstract Scope: There is a dearth of studies demonstrating the use of dietary biomarkers for determination of food intake. The objective of this study was to develop calibration curves for use in quantifying citrus intakes in an independent cohort. Methods and results: Participants (n=50) from the NutriTech food-intake study consumed standardized breakfasts for three consecutive days over three consecutive weeks. Orange juice intake decreased over the weeks. Urine samples were analyzed by NMR-spectroscopy and proline betaine was quantified and normalized to osmolality. Calibration curves were developed and used to predict citrus intake in an independent cohort; the Irish National Adult Nutrition Survey (NANS) (n=565). Proline betaine displayed a dose-response relationship to orange juice intake in 24h and fasting samples (p<0.001). In a test set, predicted orange juice intakes displayed excellent agreement with true intake. There were significant associations between predicted intake measured in 24h and fasting samples and true intake(r=0.710- 0.919). Citrus intakes predicted for the NANS cohort demonstrated good agreement with self-reported intake and this agreement improved following normalization to osmolality. Conclusion: The developed calibration curves successfully predicted citrus intakes in an independent cohort. Expansion of this approach to other foods will be important for the development of objective intake measurements. en
dc.description.sponsorship Department of Agriculture, Food and the Marine en
dc.description.sponsorship European Research Council en
dc.description.sponsorship Health Research Board en
dc.description.sponsorship Science Foundation Ireland en
dc.language.iso en en
dc.publisher Wiley en
dc.rights This is the author's version of the following article: Gibbons, H.; Michielsen, C.J.R.; Rundle, M.; Frost, G.; McNulty, B.A.; Nugent, A.P.; Walton, J.; Flynn, A.; Gibney, M.J.; Brennan, L. untranslated (2017) "Demonstration of the utility of biomarkers for dietary intake assessment; proline betaine as an example" Molecular Nutrition and Food Research, 61 (10) : which has been published in final form at en
dc.subject Citrus fruit en
dc.subject Dietary assessment en
dc.subject Dose-response en
dc.subject Metabolomics en
dc.subject Proline betaine en
dc.title Demonstration of the utility of biomarkers for dietary intake assessment; proline betaine as an example en
dc.type Journal Article en
dc.status Peer reviewed en
dc.identifier.volume 61
dc.identifier.issue 10
dc.identifier.doi 10.1002/mnfr.201700037
dc.neeo.contributor Gibbons|Helena|aut|
dc.neeo.contributor Michielsen|Charlotte J. R.|aut|
dc.neeo.contributor Rundle|Milena|aut|
dc.neeo.contributor McNulty|Breige A.|aut|
dc.neeo.contributor Nugent|Anne P.|aut|
dc.neeo.contributor Gibney|Michael J.|aut|
dc.neeo.contributor Brennan|Lorraine|aut|
dc.neeo.contributor et al.||aut|
dc.description.othersponsorship NutriTech en
dc.internal.rmsid 749850575 2017-05-16T13:19:04Z

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