Prevalence of Heavy Alcohol Use Among People Receiving Methadone Following Change to Methadose

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dc.contributor.author Klimas, Jan
dc.contributor.author Wood, Evan
dc.contributor.author Nosova, Ekaterina
dc.contributor.author et al.
dc.date.accessioned 2017-10-10T13:42:22Z
dc.date.copyright 2017 Taylor & Francis en
dc.date.issued 2017-06
dc.identifier.citation Substance Use and Misuse en
dc.identifier.uri http://hdl.handle.net/10197/9001
dc.description.abstract BACKGROUND: A recent switch in methadone formulation from methadone (1 mg/mL) to Methadose (10 mg/mL) in British Columbia (BC), Canada, was associated with increased reports of opioid withdrawal and increases in illicit opioid use. Impacts on other forms of drug use have not been assessed. Since alcohol use is common among people receiving Medication-Assisted Treatment (MAT), we assessed if switch was associated with increased prevalence of heavy alcohol use. METHODS: Drawing on data from two open prospective cohort studies of people who inject drugs in Vancouver, BC, generalized estimating equations (GEE) model examined relationship between methadone formulation change and heavy alcohol use, defined by National Institute for Alcohol Abuse and Alcoholism (NIAAA). A sub-analysis examined relationship with heavier drinking defined as at least eight drinks per day on average in last six months. RESULTS: Between June 2013 and May 2015, a total of 787 participants on methadone were eligible for the present analysis, of which 123 (15.6%) reported heavy drinking at least once in last six months. In an unadjusted GEE model, Methadose use was not significantly associated with an increased likelihood of heavy drinking [Odds Ratio (OR) = 1.03; 95% Confidence interval (CI) = 0.87-1.21]. Methadose use was not significantly associated with an increased likelihood of drinking at least eight drinks daily on average (OR = 1.09, 95% CI = 0.72-1.65). CONCLUSIONS: Despite reported changes in opioid use patterns coinciding with the change, there appeared to be no effect of the methadone formulation change on heavy drinking in this setting. en
dc.description.sponsorship European Commission en
dc.description.sponsorship Irish Research Council en
dc.language.iso en en
dc.publisher Taylor & Francis en
dc.rights This is an electronic version of an article published in Klimas, Jan, Wood, Evan, Nosova, Ekaterina, et al. : Prevalence of Heavy Alcohol Use Among People Receiving Methadone Following Change to Methadose. Substance Use and Misuse, 201. Substance Use and Misuse is available online at: www.tandfonline.com/doi/abs/10.1080/10826084.2017.1302960 en
dc.subject Addiction en
dc.subject Alcohol en
dc.subject Methadone maintenance treatment en
dc.subject Heroin en
dc.subject Longitudinal study en
dc.subject Formulation en
dc.subject Medication assisted treatment (MAT) en
dc.subject Opioid use disorder en
dc.title Prevalence of Heavy Alcohol Use Among People Receiving Methadone Following Change to Methadose en
dc.type Journal Article en
dc.internal.authorcontactother jan.klimas@ucd.ie
dc.internal.webversions https://www.ncbi.nlm.nih.gov/pubmed/28605308
dc.check.info Check for published version en
dc.status Peer reviewed en
dc.check.date 2018-04-10
dc.identifier.doi 10.1080/10826084.2017.1302960
dc.neeo.contributor Klimas|Jan|aut|
dc.neeo.contributor Wood|Evan|aut|
dc.neeo.contributor Nosova|Ekaterina|aut|
dc.neeo.contributor et al.||aut|
dc.date.embargo 2018-06-12
dc.description.othersponsorship US National Institutes of Health en
dc.description.othersponsorship Canada Research Chairs program en
dc.description.othersponsorship Michael Smith Foundation for Health Research en
dc.description.othersponsorship NG Biomed, Ltd. en
dc.description.othersponsorship ELEVATE grant en
dc.internal.rmsid 767822175
dc.date.updated 2017-06-27T17:34:17Z
 Access to this item has been restricted by the copyright holder until: 2018-06-12

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