Veterinary Medicine Research Collection
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Browsing Veterinary Medicine Research Collection by Type "Conference Publication"
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- PublicationApplying Haddon’s matrix to bovine injury prevention: An example using white line disease(World Association for Buiatrics, 2016-07-08)
; ; ;Haddon’s matrix is a model used to conceptualize injury occurrence. This model defines injury as energy transfer, by the agent to the host, in quantities or rates exceeding the tolerance of the host’s tissue. While this approach has been used in human injury research for over 30 years to identify risk factors and develop preventive interventions, we have not seen it applied to animal injury. Lameness, an etiologically complex condition, is a source of both economic losses and welfare concerns to the cattle industry. We introduce Haddon’s matrix as an approach to viewing traumatic animal injury using bovine white line disease as an example. 62
- PublicationBasic behavioural triage and first aid(2016-03-06)When a pet has behavioural issues, the client often seeks advice from many different sources before approaching the veterinary practice for advice. This may be because they are not aware that veterinary staff can assist with behavioural problems (Martin et al., 2014).
- PublicationComparative ocular gene therapy: How curing inherited blindness in Briard dogs benefits everyone(2019-08-11)Laboratory animals (zebrafish, rodents, rabbits, dogs and primates) have been used for decades to model various forms of ocular disease and in the discovery and development of therapeutics. Leber congenital amaurosis (LCA, OMIM # 20400) is a family of rare, inherited, early-onset severe retinal degenerations (EOSRDs) which affects 1 in 80,000 and presents in infancy.
46Scopus© Citations 3
- PublicationComputational selection of novel antigenic targets in the Mycobacterium bovis proteome(2014-06-27)
; ; ; ;The discovery of novel antigens is an essential requirement in devising new diagnostics for use in both M. tuberculosis (Mtb) and M. bovis control programmes. Reverse vaccinology is now a feasible method of extracting potential immunogenic epitopes from bacterial genomes to reduce the cost of experimental screening of antigens for anamnestic responses in infected hosts. Since a significant focus has been on the role of CD4+ T cells, the ability to predict peptide binding to MHC-II molecules is seen as a key step in discovery.Previous antigen-mining experiments for identification of novel diagnostic or vaccine candidates for human and bovine TB follow a targeted approach, where specific groups of proteins suspected to contain likely candidates are identified and evaluated for mmunogenicity. A disadvantage of those approaches is that they are restricted to a relatively small set of proteins biased by the initial selection criteria. Our objective was to computationally select antigens in a less biased manner. 154
- PublicationEffect of seasons on the proximate composition of Laminaria hyperborea from Irish Atlantic coast(2018-10-27)
; ; ; ;This study aimed to analyze the seasonal variation in the proximate composition of Laminaria hyperborea collected in 2016 and 2017, off the west coast of Ireland. 29
- PublicationThe effects of corticosteroid drugs on the visual function of zebrafish(British Pharmacological Society, 2018-04-01)
;Introduction: Glaucoma, a leading cause of blindness, is a heterogenous eye condition characterized by gradual loss of visual acuity due to degeneration of retinal ganglion cells (1). Glaucoma is an off-target effect of corticosteroids when administered intraocularly for treatment of some ocular indications (2). This study uses zebrafish to study whether a glaucoma-type disease is induced by treatment with corticosteroids by assessing the effects on retinal histology and visual function. 96
- PublicationEmerging Drug Therapies for Inherited Retinal Dystrophies(Springer, 2019-12-29)Worldwide, 1 in 2000 people suffer from inherited retinal dystrophies (IRD). Individuals with IRD typically present with progressive vision loss that ultimately results in blindness. Unfortunately, effective treatment options are not widely available due to the genetic and clinical heterogeneity of these diseases. There are multiple gene, cell, and drug-based therapies in various phases of clinical trials for IRD. This mini-review documents current progress made in drug-based clinical trials for treating IRD.
271Scopus© Citations 6
- PublicationExploring ultrasound-assisted extraction to recover high valuable polysaccharides from brown macroalgae and its related antioxidant activities(2018-10-27)
; ; ; ;This study aimed to optimize the ultrasound-assisted extraction (UAE) parameters of temperature, time and amplitude on the yields of fucose and glucans and their antioxidant activities (FRAP and DPPH) of extracts from Laminaria digitata and to evaluate the application of these optimum UAE parameters in other brown macroalgae (L. hyperborea and Ascophyllum nodosum). 25
- PublicationInvestigation of the role of cysteinyl leukotrienes in ocular developmental angiogenesis(Association for Research in Vision and Opthalmology, 2016-09)
; ; ; ; ; ;Previously, we identified quininib (2-[(E)-2-(quinolin-2-yl)vinyl] phenol) and a related series of cysteinyl leukotriene (cysLT) receptor antagonists which inhibit hyaloid vessel development in zebrafish eyes. Here, we more comprehensively characterise the expression and function of specific cysLT signalling components in ocular developmental angiogenesis. 35
- PublicationStructure-activity relationship of a novel family of cysteinyl leukotriene receptor antagonist quinoline compounds with anti-angiogenic activity(British Pharmacological Society, 2017-04-01)
; ; ; ; ; ; ; ; ; ; ;Introduction: Previously, we identified quininib (2-[(E)-2-(quinolin-2-yl)vinyl]phenol), a cysteinyl leukotriene receptor antagonist with anti-angiogenic and anti-permeable activity (1,2). Here, we report a structure activity relationship study to more comprehensively characterise features which confer anti-angiogenic activity. 26