Collection Statistics: Systems Biology Ireland

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Downloads by

Region Downloads
NA - North America 54680
EU - Europe 19940
AS - Asia, other 14623
AF - Africa 972
OC - Oceania 739
SA - South America 572
Total 91526
Country Downloads
US - United States of America 53321
CN - China 6999
IE - Ireland 3816
DE - Germany 3517
FR - France 2841
GB - United Kingdom 2334
IN - India 1824
JP - Japan 1183
CA - Canada 1124
RU - Russian Federation 1029
other - Other Country 14562
Total 92550
City Downloads
Ashburn 15610
Fairfield 6981
San Jose 3871
Dublin 2571
Buffalo 1680
Jupiter 1627
Beijing 1625
Chicago 1618
Mountain View 1043
State College 816
other 39311
Total 76753
Most downloaded files Downloads
[Systems biology embedded target validation: improving efficacy in drug discovery] - ID: 22106 - Systems biology embedded target validation improving efficacy in drug discovery.pdf 2699
[Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance] - ID: 13848 - Paper101.pdf 2071
[Recommendations for Biomarker Identification and Qualification in Clinical Proteomics] - ID: 13838 - Paper129.pdf 2056
[Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche] - ID: 13984 - Paper8.pdf 2007
[GSK3 inhibitors regulate MYCN mRNA levels and reduce neuroblastoma cell viability through multiple mechanisms including p53 and Wnt signalling] - ID: 22095 - GSK3 inhibitors regulate MYCN mRNA levels and reduce neuroblastoma cell.pdf 1684
[Doxorubicin induces the DNA damage response in cultured human mesenchymal stem cells] - ID: 13946 - Paper109.pdf 1286
[The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in sheep and goats] - ID: 14970 - paper209.pdf 1133
[The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier] - ID: 13962 - Paper68.pdf 1125
[Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients] - ID: 22105 - Signaling pathway models as biomarkers Patient specific simulations of JNK activity predict the survival of neuroblastoma patients.pdf 1082
[Development of a thermoresponsive chitosan gel combined with human mesenchymal stem cells and desferrioxamine as a multimodal pro-angiogenic therapeutic for the treatment of critical limb ischaemia] - ID: 14974 - Paper211.pdf 1036
[The role of progesterone in implantation and trophoblast invasion] - ID: 13822 - Paper119.pdf 1020
[Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells] - ID: 14994 - Paper3.pdf 979
[Liposomal gene delivery mediated by tissue-engineered scaffolds] - ID: 13828 - Paper122.pdf 935
[Opioid mediated activity and expression of mu and delta opioid receptors in isolated human term non-laboring myometrium] - ID: 9915 - EJPharm_revision_JOC.pdf 929
[Big Signals from Small Particles: Regulation of Cell Signaling Pathways by Nanoparticles] - ID: 14986 - Paper216.pdf 903
[The role of HIF in immunity and inflammation] - ID: 28601 - The role of HIF in immunity and inflammation. CTaylor.pdf 892
[Progress in the Formulation and Delivery of Somatostatin Analogues for Acromegaly] - ID: 27615 - Fattah_&_Brayden_Ther_Del_RMS.pdf 891
[Mesenchymal Stem Cells and Osteoarthritis: Remedy or Accomplice?] - ID: 13866 - Paper142.pdf 879
[Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells] - ID: 13862 - Paper14.pdf 813
[Hypoxia, innate immunity and infection in the lung] - ID: 15018 - Paper200.pdf 811
[HGF induces epithelial-to-mesenchymal transition by modulating the mammalian Hippo/MST2 and ISG15 pathways] - ID: 22097 - HGF induces epithelial to mesenchymal transition by modulating the mammalian HippoMST2 and ISG15 pathways.pdf 791
[High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix] - ID: 14980 - Paper213.pdf 730
[It takes two to tango—signalling by dimeric Raf kinases] - ID: 13922 - Paper41.pdf 704
[Inferring Signaling Pathway Topologies from Multiple Perturbation Measurements of Specific Biochemical Species] - ID: 13974 - Paper73.pdf 692
[The electrical stimulation of carbon nanotubes to provide a cardiomimetic cue to MSCs] - ID: 13844 - Paper131.pdf 686
[Isolation and Phenotypic Characterisation of Stem Cells from Late Stage Osteoarthritic Mesenchymal Tissues] - ID: 14956 - Labusca_CSCRT 2ND revised.pdf 675
[Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT)] - ID: 13834 - Paper127.pdf 654
[Signalling by protein phosphatases and drug development: a systems-centred view] - ID: 15004 - Paper97.pdf 652
[Thermoresponsive Substrates used for the Expansion of Human Mesenchymal Stem Cells and the Preservation of Immunophenotype] - ID: 13846 - Paper133.pdf 618
[Mechanochemical Stimulation of MCF7 Cells with Rod-Shaped Fe-Au Janus Particles Induces Cell Death through Paradoxical Hyperactivation of ERK] - ID: 22098 - Mechanochemical Stimulation of MCF7 Cells with Rod-Shaped Fe-Au Janus Particles Induces Cell Death through Paradoxical Hyperactivation of ERK.pdf 610
[PTEN Protein Phosphatase Activity Correlates with Control of Gene Expression and Invasion, a Tumor-Suppressing Phenotype, But Not with AKT Activity] - ID: 13858 - Paper138.pdf 601
[Proapoptotic Kinase MST2 Coordinates Signaling Crosstalk between RASSF1A, Raf-1, and Akt] - ID: 13978 - Paper75.pdf 601
[Genetic Interaction Mapping Reveals a Role for the SWI/SNF Nucleosome Remodeler in Sploceosome Activation in Fission Yeast] - ID: 28640 - Genetic Interaction Mapping Reveals a Role for the SWI SNF Nucleosome.PDF 592
[Impact of Mesenchymal Stem Cell secreted PAI-1 on colon cancer cell migration and proliferation] - ID: 13826 - Paper120.pdf 586
[Mutant K-Ras Activation of the Proapoptotic MST2 Pathway Is Antagonized by Wild-Type K-Ras] - ID: 13982 - Paper79.pdf 581
[HiQuant: Rapid postquantification analysis of large-scale MS-generated proteomics data] - ID: 28592 - HiQuant Rapid post-quantification analysis of large scale MS generated Proteomics Data JRauch.pdf 577
[Compassionate use of interventions: results of a European Clinical Research Infrastructures Network (ECRIN) survey of ten European countries] - ID: 13876 - Paper146.pdf 572
[Monitoring of cell oxygenation and responses to metabolic stimulation by intracellular oxygen sensing technique] - ID: 13864 - Paper140.pdf 569
[The complexities and versatility of the RAS-to-ERK signalling system in normal and cancer cells] - ID: 28604 - v4 Fey Complexity of RAS-ERK signalling.pdf 543
[In vitro Characterization of an Electroactive Carbon-Nanotube-Based Nanofiber Scaffold for Tissue Engineering] - ID: 13832 - Paper125.pdf 541
[A brain-derived neurotrophic factor mimetic is sufficient to restore cone photoreceptor visual function in an inherited blindness model] - ID: 28394 - 2017_Daly_Sci_Rep.pdf 538
[Advances in mesenchymal stem cell-mediated gene therapy for cancer] - ID: 13812 - Paper112.pdf 533
[A role for adrenergic receptors in the uterotonic effects of ergometrine in isolated human term non-laboring myometrium] - ID: 25014 - AA-D-16-00106_2_Columns.pdf 522
[In vitro study of the interaction of heregulin-functionalized magnetic-optical nanorods with MCF7 and MDA-MB- 231 cells] - ID: 25373 - Faraday_Discussion_175_2014_-_In_vitro_study_of_the_interaction_of_heregulin.pdf 521
[Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells] - ID: 20553 - Weiner-Gorzel_et_al-2015-Cancer_Medicine.pdf 515
[NFκB and HIF display synergistic behaviour during hypoxic inflammation] - ID: 13976 - Paper74.pdf 506
[PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells] - ID: 14978 - Paper1.pdf 502
[Strategies for improved targeting of therapeutic cells: implications for tissue repair] - ID: 13918 - Paper4.pdf 496
[Primary cilium-associated genes mediate bone marrow stromal cell response to hypoxia] - ID: 22101 - Primary cilium-associated genes mediate bone marrow stromal cell response to hypoxia.pdf 495
[Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function] - ID: 15020 - Paper201.pdf 487
[Mesenchymal Stromal Cells Protect Endothelial Cells from Cytotoxic T Lymphocyte-Induced Lysis] - ID: 28690 - Mesenchymal stem cells protect endothelial cells from cytotoxic T lymphocyte induced lysis-1.pdf 481
Total 43402


Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Tot
2017 00 0000 0000 0584 584
2018 1178587 633495648127 540145916477 197159 6102
2019 169261 563123021242134 1483179518873226 17791641 18292
2020 17461647 19009601249727 976106111841306 15181169 15443
2021 15731226 9949221148800 103313507031484 1437804 13474
2022 1107517 7169932304939 45591421111301 1224106 12687
Ever 92703