Now showing 1 - 2 of 2
  • Publication
    Effect of dispersive conductivity and permittivity in volume conductor models of deep brain stimulation
    The aim of this study was to examine the effect of dispersive tissue properties on the volume-conducted voltage waveforms and volume of tissue activated during deep brain stimulation. Inhomogeneous finite-element models were developed, incorporating a distributed dispersive electrode–tissue interface and encapsulation tissue of high and low conductivity, under both current controlled and voltage-controlled stimulation. The models were used to assess the accuracy of capacitive models, where material properties were estimated at a single frequency, with respect to the full dispersive models. The effect of incorporating dispersion in the electrical conductivity and relative permittivity was found to depend on both the applied stimulus and the encapsulation tissue surrounding the electrode. Under current-controlled stimulation, and during voltage-controlled stimulation when the electrode was surrounded by high-resistivity encapsulation tissue, the dispersive material properties of the tissue were found to influence the voltage waveform in the tissue, indicated by RMS errors between the capacitive and dispersive models of 20%–38% at short pulse durations. When the dispersive model was approximated by a capacitive model, the accuracy of estimates of the volume of tissue activated was very sensitive to the frequency at which material properties were estimated.When material properties at 1 kHz were used, the error in the volume of tissue activated by capacitive approximations was reduced to −4.33% and 11.10%, respectively, for current controlled and voltage-controlled stimulations, with higher errors observed when higher or lower frequencies were used.
    Scopus© Citations 52  1198
  • Publication
    Simulation of cortico-basal ganglia oscillations and their suppression by closed loop deep brain stimulation
    A new model of deep brain stimulation is presented that integrates volume conduction effects with a neural model of pathological beta-band oscillations in the cortico-basal ganglia network. The model is used to test the clinical hypothesis that closed-loop control of the amplitude of DBS may be possible, based on the average rectified value of beta-band oscillations in the local field potential. Simulation of closed-loop high-frequency Deep Brain Stimulation was shown to yield energy savings, with the magnitude of the energy saved dependent on the strength of coupling between the subthalamic nucleus and the remainder of the cortico-basal ganglia network. When closed-loop DBS was applied to a strongly coupled cortico-basal ganglia network, the stimulation energy delivered over a 480 s period was reduced by up to 42 %. Greater energy reductions were observed for weakly coupled networks, as the stimulation amplitude reduced to zero once the initial desynchronization had occurred. The results provide support for the application of closed-loop highfrequency DBS based on electrophysiological biomarkers.
    Scopus© Citations 28  751