Heslin, Caitlin

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Heslin, Caitlin
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Heslin, Caitlin

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  • Publication
    Corrigendum: Biomolecules as Model Indicators of In Vitro and In Vivo Cold Plasma Safety
    (Frontiers Media, 2021-04-14)
    Heslin, Caitlin 
    ;
    Boehm, Daniela 
    ;
    Gilmore, Brendan F. 
    ;
    Bourke, Paula 
    ;
    et al. 
    In the original article, the reference for [16] was incorrectly written as “Khlyustova A, Jarzina F, Brinckmann S. Important parameters in plasma jets for the production of RONS in liquids for plasma medicine: a brief review. Front Chem Sci Eng (2019) 13:238–52. doi: 10.1007/s11705-019- 1801-8.” This should be “Khlyustova A, Labay C, Machala Z, Ginebra MP, Canal C. Important parameters in plasma jets for the production of RONS in liquids for plasma medicine: a brief review. Front Chem Sci Eng (2019) 13:238–52. doi: 10.1007/s11705-019-1801-8.” Further, the reference for [17] was incorrectly written as “Labay C, Shimizu T, Thomas HM, Morfill GE. Enhanced generation of reactive species by cold plasma in gelatin solutions for selective cancer cell death. ACS Appl Mater Interfaces (2020) 12(42):47256–69. doi: 10.1021/acsami.0c12930.” This should be “Labay, C, Roldán, M, Tampieri, F, Stancampiano, A, Escot Bocanegra, P, Ginebra, MP, Canal, C. Enhanced generation of reactive species by cold plasma in gelatin solutions for selective cancer cell death. ACS Appl Mater Interfaces (2020) 12(42):47256–69. doi: 10.1021/acsami.0c12930.” The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
      189
  • Publication
    Biomolecules as Model Indicators of In Vitro and In Vivo Cold Plasma Safety
    (Frontiers Media, 2021-01-14)
    Heslin, Caitlin 
    ;
    Boehm, Daniela 
    ;
    Gilmore, Brendan F. 
    ;
    Bourke, Paula 
    ;
    et al. 
    The potential applications for cold plasma in medicine are extensive, from microbial inactivation and induction of apoptosis in cancer cells to stimulating wound healing and enhancing the blood coagulation cascade. The safe bio-medical application of cold plasma and subsequent effect on complex biological pathways requires precision and a distinct understanding of how physiological redox chemistry is manipulated. Chemical modification of biomolecules such as carbohydrates, proteins, and lipids treated with cold plasma have been characterized, however, the context of how alterations of these molecules affect cell behavior or in vivo functionality has not been determined. Thus, this study examines the cytotoxic and mutagenic effects of plasma-treated molecules in vitro using CHO-K1 cells and in vivo in Galleria mellonella larvae. Specifically, albumin, glucose, cholesterol, and arachidonic acid were chosen as representative biomolecules, with established involvement in diverse bioprocesses including; cellular respiration, intracellular transport, cell signaling or membrane structure. Long- and short-term effects depended strongly on the molecule type and the treatment milieu indicating the impact of chemical and physical modifications on downstream biological pathways. Importantly, absence of short-term toxicity did not always correlate with absence of longer-term effects, indicating the need to comprehensively assess ongoing effects for diverse biological applications.
      147Scopus© Citations 3