Now showing 1 - 10 of 26
  • Publication
    3D Power Doppler ultrasound and computerised placental assessment in normal pregnancy
    Background: In recent years there have been significant developments in the use of 3D Power Doppler (3DPD) imaging and quantitative 3DPD histogram analysis to estimate both placental volume and intra-placental vasculature. This study aims to determine if placental volume, vascularisation and blood flow are correlated with gestational age in normal pregnancy. It also examines whether or not a new software method for analysis of percentage calcification (the ‘placentometer’) correlates well with gestation. Material and method: This was a prospective cohort study of 250 women with normal pregnancies (12 + 6 to 39 + 5 weeks gestation). 3DPD ultrasound was used to evaluate placental volume, vascularisation index (VI), flow index (FI) and vascularisation-flow index (VFI). Placental volume (calculated at 35–40 weeks gestation), was correlated with birth weight. Following each scan the percentage of calcification was also calculated using the placentometer. Results: Placental volume correlated significantly with gestational age: 66.676 + 0.623 × GA (P < 0.001). No significant change with gestation was noted in VI, FI and VFI (VI: P = 0.199, FI: P = 0.299, VFI: P = 0.557). Software analysis of the percentage of calcification, demonstrated the expected increase in calcification as gestation increased: −4.605 + 0.032 × GA (P < 0.001). From 35 to 40 weeks gestation volume was related to birth weight (P < 0.01). Conclusion: This study shows that in normal low-risk pregnancy placental volume increases with gestational age, whereas vascularisation and blood flow are independent of gestation. Placental volume in late pregnancy is related to birth weight. Software analysis of the percentage of calcification demonstrates an increase with advancing gestation.
      407Scopus© Citations 5
  • Publication
    Lower Limb Interjoint Postural Coordination One Year after First-Time Lateral Ankle Sprain
    Introduction: Longitudinal analyses of participants with a history of lateral ankle sprain are lacking. This investigation combined measures of lower limb interjoint coordination and stabilometry to evaluate static unipedal stance with the eyes open (condition 1) and closed (condition 2) in a group of participants with chronic ankle instability (CAI) compared to lateral ankle sprain ‘‘copers’’ (both recruited 12 months after sustaining an acute first-time lateral ankle sprain) and a group of noninjured controls. Methods: Twenty-eight participants with CAI, 42 lateral ankle sprain ‘‘copers,’’ and 20 noninjured controls completed three 20-s singlelimb stance trials in conditions 1 and 2. An adjusted coefficient of multiple determination statistic was used to compare stance limb threedimensional kinematic data for similarity to establish patterns of interjoint coordination. The fractal dimension of the stance limb center of pressure path was also calculated. Results: Between-group analyses revealed that participants with CAI displayed notable increases in ankle–hip linked coordination compared with both lateral ankle sprain ‘‘copers’’ (j0.52 (1.05) vs 0.28 (0.9), P = 0.007) and controls (j0.52 (1.05) vs 0.63 (0.64), P = 0.006) in condition 1 and compared with controls only (0.62 (1.92) vs 0.1 (1.0) P = 0.002) in condition 2. Participants with CAI also exhibited a decrease in the fractal dimension of the center-of-pressure path during condition 2 compared with both controls and lateral ankle sprain ‘‘copers.’’ Conclusions: Participants with CAI present with a hip-dominant strategy of eyes-open and eyes-closed static unipedal stance. This coincided with reduced complexity of the stance limb center of pressure path in the eyes-closed condition.
      457Scopus© Citations 18
  • Publication
    Single-leg drop landing movement strategies 6 months following first-time acute lateral ankle sprain injury
    No research exists predicating a link between acute ankle sprain injury-affiliated movement patterns and those of chronic ankle instability (CAI) populations. The aim of the current study was to perform a biomechanical analysis of participants, 6 months after they sustained a first-time acute lateral ankle sprain (LAS) injury to establish this link. Fifty-seven participants with a 6-month history of first-time LAS and 20 noninjured participants completed a single-leg drop landing task on both limbs. Three-dimensional kinematic (angular displacement) and sagittal plane kinetic (moment of force) data were acquired for the joints of the lower extremity, from 200 ms pre-initial contact (IC) to 200 ms post-IC. Individual joint stiffnesses and the peak magnitude of the vertical component of the ground reaction force (GRF) were also computed. LAS participants displayed increases in hip flexion and ankle inversion on their injured limb (P < 0.05); this coincided with a reduction in the net flexion-extension moment at the hip joint, with an increase in its stiffness (P < 0.05). There was no difference in the magnitude of the peak vertical GRF for either limb compared with controls. These results demonstrate that altered movement strategies persist in participants, 6 months following acute LAS, which may precipitate the onset of CAI.
      966Scopus© Citations 37
  • Publication
    A review of cross sectional imaging, ultrasound & nuclear medicine utilisation patterns in paediatric patients in Ireland, 2003-12
    (British Institute of Radiology, 2015-02-26) ; ;
    Objective: Recent trends in paediatric imaging have been examined in Australia and the USA. Such literature in Europe is sparse, incomprehensive and outdated. This research investigated (1) population-based trends in the use of advanced medical imaging in children in Ireland from 2003 to 2012; (2) its use across age and gender; and (3) the most commonly performed examinations within each modality. Methods: A retrospective cohort analysis study was carried out within Irish paediatric hospitals. All CT, MRI, ultrasound and nuclear medicine (NM) annual examination data from 2003 to 2012 was obtained from radiology information systems. Results: 224,173 imaging procedures were carried out on 84,511 patients, 68% of which were ultrasound, 15% were MRI, 11% were CT and 6% were NM. Between 2003 and 2012, MRI (+280%) and CT (+80%) saw the largest increases in use, followed by ultrasound (+67%) and NM (+10%). Almost half of the study population were less than 3 years old. CT imaging was more frequent than MR in 2005. By 2012, MR rates were twice that of CT. CT imaging rates were the lowest in the youngest age categories. Conclusion: Advanced imaging use, particularly MRI, has risen substantially over the past 10 years. The utilization of non-ionizing modalities increased between 2003 and 2012, especially in brain, spinal and abdominal imaging. MR is now used at twice the frequency of CT. Advances in knowledge: Longitudinal advanced imaging utilization trends, including CT trends, have been established in the Irish paediatric population.
      342Scopus© Citations 5
  • Publication
    Laboratory Measures of Postural Control During the Star Excursion Balance Test After Acute First-Time Lateral Ankle Sprain
    Context: No researchers, to our knowledge, have investigated the immediate postinjury-movement strategies associated with acute first-time lateral ankle sprain (LAS) as quantified by center of pressure (COP) and kinematic analyses during performance of the Star Excursion Balance Test (SEBT). Objective: To analyze the kinematic and COP patterns of a group with acute first-time LAS and a noninjured control group during performance of the SEBT. Design: Case-control study. Setting: University biomechanics laboratory. PATIENTS OR Other particpants: A total of 81 participants with acute first-time LAS (53 men, 28 women; age = 23.22 ± 4.93 years, height = 1.73 ± 0.09 m, mass = 75.72 ± 13.86 kg) and 19 noninjured controls (15 men, 4 women; age = 22.53 ± 1.68 years, height = 1.74 ± 0.08 m, mass = 71.55 ± 11.31 kg). Intervention: Participants performed the anterior (ANT), posterolateral (PL), and posteromedial (PM) reach directions of the SEBT. Main outcome Measure(s): We assessed 3-dimensional kinematics of the lower extremity joints and associated fractal dimension (FD) of the COP path during performance of the SEBT. Results: The LAS group had decreased normalized reach distances in the ANT, PL, and PM directions when compared with the control group on their injured (ANT: 58.16% ± 6.86% versus 64.86% ± 5.99%; PL: 85.64% ± 10.62% versus 101.14% ± 8.39%; PM: 94.89% ± 9.26% versus 107.29 ± 6.02%) and noninjured (ANT: 60.98% ± 6.74% versus 64.76% ± 5.02%; PL: 88.95% ± 11.45% versus 102.36% ± 8.53%; PM: 97.13% ± 8.76% versus 106.62% ± 5.78%) limbs (P < .01). This observation was associated with altered temporal sagittal-plane kinematic profiles throughout each reach attempt and at the point of maximum reach (P < .05). This result was associated with a reduced FD of the COP path for each reach direction on the injured limb only (P < .05). Conclusions: Acute first-time LAS was associated with bilateral deficits in postural control, as evidenced by the bilateral reduction in angular displacement of the lower extremity joints and reduced reach distances and FD of the COP path on the injured limb during performance of the SEBT.
      403Scopus© Citations 52
  • Publication
    Concussion is associated with altered preparatory postural adjustments during gait initiation
    Gait initiation is a useful surrogate measure of supraspinal motor control mechanisms but has never been evaluated in a cohort following concussion. The aim of this study was to quantify the preparatory postural adjustments (PPAs) of gait initiation (GI) in fifteen concussion patients (4 females, 11 males) in comparison to a group of fifteen age- and sex- matched controls. All participants completed variants of the GI task where their dominant and non-dominant limbs as the stepping and support limbs. Task performance was quantified using the centre of pressure (COP) trajectory of each foot (computed from a force plate) and the centre of mass (COM) trajectory (estimated from an inertial measurement unit placed on the sacrum). Concussed patients exhibited decreased COP excursion on their dominant foot, both when it was the stepping limb (sagittal plane: 9.71mm [95% CI: 8.14 to 11.27mm] vs 14.9mm [95%CI: 12.31 to 17.49mm]; frontal plane: 36.95mm [95% CI: 30.87 to 43.03mm] vs 54.24mm [95%CI: 46.99 to 61.50mm]) and when it was the support limb (sagittal plane: 10.43mm [95% CI: 8.73 to 12.13mm] vs 18.13mm [95%CI: 14.92 to 21.35mm]; frontal plane: 66.51mm [95% CI: 60.45 to 72.57mm] vs 88.43mm [95%CI: 78.53 to 98.32mm]). This was reflected in the trajectory of the COM, wherein concussion patients exhibited lower posterior displacement (19.67mm [95%CI: 19.65mm to 19.7mm]) compared with controls (23.62mm [95%CI: 23.6 to 23.64]). On this basis, we conclude that individuals with concussion display deficits during a GI task which are potentially indicative of supraspinal impairments in motor control.
      477Scopus© Citations 14
  • Publication
    Is there a role for Placental Volume, Vasculature and Calcification in monitoring Post-term Pregnancies?
    Objectives: This study aims to assess if three dimensional power Doppler (3DPD) ultrasound of the placenta, evaluating placental volume, vascularisation, and blood flow in post-term pregnancies differs from normal. It also examines whether computer analysis identifies the increased calcification normally present in the placenta after 40 weeks. Methods: This was a prospective cohort study involving 50 women with post-term pregnancies. Gestational age (GA) ranged from 40-41+6 weeks gestation. 3DPD ultrasound was used to evaluate placental volume, vascularisation index (VI), flow index (FI) and vascularisation-flow index (VFI). Following each scan the percentage of calcification was also calculated, by computer analysis. Results were compared with previously determined normal values (36-40 weeks gestation) and correlated with Doppler values and placental histology. Results: Results showed that placental volume, VI, FI and VFI are not influenced by GA when the pregnancy has advanced beyond 40 weeks and that values are similar between post-term pregnancies and normal pregnancies between 36 and 40 weeks. Placental volume was seen to decrease in post-term pregnancies as the mean UtA PI increased (P=0.047).  FI was reduced in cases where chorangiosis was found at histology (P=0.033), identifying the increased vessel number associated with these cases. Computer analysis of placental calcification identified the increased calcification expected after 40 weeks, and also showed that calcification continues to increase between 40 and 42 weeks (P=0.029). Conclusion: This study suggests that 3DPD placental assessment may provide additional information, assisting clinicians in decision making in post-term pregnancies.
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  • Publication
    Single-leg drop landing movement strategies in participants with chronic ankle instability compared with lateral ankle sprain 'copers'
    Individuals with CAI display alterations in hip joint kinematics and energetics during a unipodal landing task compared to LAS 'copers'. These alterations may be responsible for the increased risk of injury experienced by individuals with CAI during landing manoeuvres. Thus, clinicians must recognise the potential for joints proximal to the affected ankle to contribute to impaired function following an acute lateral ankle sprain injury and to develop rehabilitation protocols accordingly.
      1180Scopus© Citations 47
  • Publication
    Poor agreement between operators on grading of the placenta
    Abnormal placental grading is associated with poor pregnancy outcome. The aim of this study was to measure intra- and interobserver variability in placental grading. Five expert sonographers independently graded 90 images on two occasions, each viewing separated by 1 week. A number of measures were employed to standardise assessment and minimise potential for variation: prior agreement was established between observers on the classifications for placental grading; a controlled viewing laboratory was used for all viewings; ambient lighting was optimal and monitors were calibrated to the GSDF standard. Kappa (κ) analysis was used to measure observer agreement. Substantial variations between individuals' scores were observed. A mean κ-value of 0.34 (range from 0.19 to 0.50) indicated fair interobserver agreement over the two occasions and only nine of the 90 images were graded the same by all five observers. Intraobserver agreement had a moderate mean κ-value of 0.52, with individual comparisons ranging from 0.45 to 0.66. This study demonstrates that, despite standardised viewing conditions, Grannum grading of the placenta is not a reliable technique even among expert observers. The need for new methods to assess placental health is required and work is ongoing to develop 2D and 3D software-based methods.
      676Scopus© Citations 18
  • Publication
    Variability of Breast Density Classification Between US and UK Radiologists
    Purpose: To assess whether subjective breast density categorization remains the most useful way to categorize mammographic breast density and whether variations exist across geographic regions with differing national legislation. Methods: Breast radiologists from two countries (UK, USA) were voluntarily recruited to review sets of anonymized mammographic images (n = 180) and additional repeated images (n = 70), totaling 250 images, to subjectively rate breast density according to the Breast Imaging Reporting and Data system (BI-RADS) categorization. Images were reviewed using standardized viewing conditions and Ziltron software. Inter-rater reliability was analyzed using the Kappa test. Results: The US radiologists (n = 25) judged fewer images as being “mostly fatty” than UK radiologists (n = 24), leading a greater number of images classified in the higher BI-RADS categories, particularly in BI-RADS 3. Overall agreement for all data sets was k = 0.654 indicating substantial agreement between the two cohorts. When the data were split into BI-RADS categories, the level of agreement varied from fair to substantial. Conclusion: Variations in how radiologists from the USA and UK classify breast density was established, especially when the data were divided into breast density categories. This variation supports the need for a reliable breast density assessment method to enhance the individualized supplemental screening pathways for dense breasts. The use of two-scale categorization method demonstrated improved agreement.
    Scopus© Citations 12  389