O'Reilly, Elaine

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O'Reilly, Elaine
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O'Reilly, Elaine

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  • Publication
    From amines to diketopiperazines: a one-pot approach
    (Elsevier, 2010-03-31)
    O'Reilly, Elaine 
    ;
    Pes, Lara 
    ;
    Paradisi, Francesca 
    An efficient one-pot synthesis is described for the preparation of 1,4-disubstituted piperazine-2,5-diones starting from a suitable amine and chloroacetyl chloride in the presence of an aqueous base. The resulting chloroacetamide is cyclised in situ by employing the phase-transfer (PT) catalyst, benzyltriethylammonium chloride (TEBA). The products are isolated in excellent yields of up to 90%.
      497Scopus© Citations 5