Options
Gormley, Isobel Claire
Preferred name
Gormley, Isobel Claire
Official Name
Gormley, Isobel Claire
Research Output
Now showing 1 - 10 of 26
- Publication
1322 - PublicationCombining biomarker and food intake dataRecent developments in biomarker discovery have demonstrated that combining biomarkers with self-reported intake data has the potential to improve estimation of food intake. Here, statistical methods for combining biomarker and self-reported food intake data are discussed. The calibration equations method is a widely applied method that corrects for measurement error in self-reported food intake data through the use of biomarker data. The method is outlined and illustrated through an example where citrus intake is estimated. In order to estimate stable calibration equations, a simulation-based framework is delineated which estimates the percentage of study subjects from whom biomarker data is required. The method of triads is frequently used to assess the validity of self-reported food intake data by combining it with biomarker data. The method is outlined and sensitivity to its underlying assumptions is illustrated through simulation studies.
180 - PublicationMetSizeR: selecting the optimal sample size for metabolomic studies using an analysis based approach(BioMed Central, 2013-11-21)
; ; ; ; Background: Determining sample sizes for metabolomic experiments is important but due to the complexity of these experiments, there are currently no standard methods for sample size estimation in metabolomics. Since pilot studies are rarely done in metabolomics, currently existing sample size estimation approaches which rely on pilot data can not be applied. Results: In this article, an analysis based approach called MetSizeR is developed to estimate sample size for metabolomic experiments even when experimental pilot data are not available. The key motivation for MetSizeR is that it considers the type of analysis the researcher intends to use for data analysis when estimating sample size. MetSizeR uses information about the data analysis technique and prior expert knowledge of the metabolomic experiment to simulate pilot data from a statistical model. Permutation based techniques are then applied to the simulated pilot data to estimate the required sample size. Conclusions: The MetSizeR methodology, and a publicly available software package which implements the approach, are illustrated through real metabolomic applications. Sample size estimates, informed by the intended statistical analysis technique, and the associated uncertainty are provided.462Scopus© Citations 90 - PublicationA Mixture of Experts Latent Position Cluster Model for Social Network DataSocial network data represent the interactions between a group of social actors. Interactions between colleagues and friendship networks are typical examples of such data. The latent space model for social network data locates each actor in a network in a latent (social) space and models the probability of an interaction between two actors as a function of their locations. The latent position cluster model extends the latent space model to deal with network data in which clusters of actors exist — actor locations are drawn from a finite mixture model, each component of which represents a cluster of actors. A mixture of experts model builds on the structure of a mixture model by taking account of both observations and associated covariates when modeling a heterogeneous population. Herein, a mixture of experts extension of the latent position cluster model is developed. The mixture of experts framework allows covariates to enter the latent position cluster model in a number of ways, yielding different model interpretations. Estimates of the model parameters are derived in a Bayesian framework using a Markov Chain Monte Carlo algorithm. The algorithm is generally computationally expensive — surrogate proposal distributions which shadow the target distributions are derived, reducing the computational burden. The methodology is demonstrated through an illustrative example detailing relationships between a group of lawyers in the USA.
621Scopus© Citations 29 - PublicationA grade of membership model for rank data(International Society for Bayesian Analysis (ISBA), 2009-06)
; A grade of membership (GoM) model is an individual level mixture model which allows individuals have partial membership of the groups that characterize a population. A GoM model for rank data is developed to model the particular case when the response data is ranked in nature. A Metropolis-withinGibbs sampler provides the framework for model fitting, but the intricate nature of the rank data models makes the selection of suitable proposal distributions difficult. 'Surrogate' proposal distributions are constructed using ideas from optimization transfer algorithms. Model fitting issues such as label switching and model selection are also addressed. The GoM model for rank data is illustrated through an analysis of Irish election data where voters rank some or all of the candidates in order of preference. Interest lies in highlighting distinct groups of voters with similar preferences (i.e. 'voting blocs') within the electorate, taking into account the rank nature of the response data, and in examining individuals’ voting bloc memberships. The GoM model for rank data is fitted to data from an opinion poll conducted during the Irish presidential election campaign in 1997.303Scopus© Citations 35 - PublicationAnalysis of Irish third-level college applications dataThe Irish college admissions system involves prospective students listing up to 10 courses in order of preference on their application. Places in third-level educational institutions are subsequently offered to the applicants on the basis of both their preferences and their final second-level examination results. The college applications system is a large area of public debate in Ireland. Detractors suggest that the process creates artificial demand for 'high profile' courses, causing applicants to ignore their vocational callings. Supporters argue that the system is impartial and transparent. The Irish college degree applications data from the year 2000 are analysed by using mixture models based on ranked data models to investigate the types of application behaviour that are exhibited by college applicants. The results of this analysis show that applicants form groups according to both the discipline and the geographical location of their course choices. In addition, there is evidence of the suggested 'points race' for high profile courses. Finally, gender emerges as an influential factor when studying course choice behaviour.
605Scopus© Citations 47 - PublicationCombining biomarker and self-reported dietary intake data: a review of the state of the art and an exposition of conceptsClassical approaches to assessing dietary intake are associated with measurement error. In an effort to address inherent measurement error in dietary self-reported data there is increased interest in the use of dietary biomarkers as objective measures of intake. Furthermore, there is a growing consensus of the need to combine dietary biomarker data with self-reported data. A review of state of the art techniques employed when combining biomarker and self-reported data is conducted. Two predominant methods, the calibration method and the method of triads, emerge as relevant techniques used when combining biomarker and self-reported data to account for measurement errors in dietary intake assessment. Both methods crucially assume measurement error independence. To expose and understand the performance of these methods in a range of realistic settings, their underpinning statistical concepts are unified and delineated, and thorough simulation studies are conducted. Results show that violation of the methods' assumptions negatively impacts resulting inference but that this impact is mitigated when the variation of the biomarker around the true intake is small. Thus there is much scope for the further development of biomarkers and models in tandem to achieve the ultimate goal of accurately assessing dietary intake.
701Scopus© Citations 15 - PublicationInfinite Mixtures of Infinite Factor Analysers(International Society for Bayesian Analysis, 2020-09)
; ; Factor-analytic Gaussian mixtures are often employed as a model-based approach to clustering high-dimensional data. Typically, the numbers of clusters and latent factors must be fixed in advance of model fitting. The pair which optimises some model selection criterion is then chosen. For computational reasons, having the number of factors differ across clusters is rarely considered. Here the infinite mixture of infinite factor analysers (IMIFA) model is introduced. IMIFA employs a Pitman-Yor process prior to facilitate automatic inference of the number of clusters using the stick-breaking construction and a slice sampler. Automatic inference of the cluster-specific numbers of factors is achieved using multiplicative gamma process shrinkage priors and an adaptive Gibbs sampler. IMIFA is presented as the flagship of a family of factor-analytic mixtures. Applications to benchmark data, metabolomic spectral data, and a handwritten digit example illustrate the IMIFA model’s advantageous features. These include obviating the need for model selection criteria, reducing the computational burden associated with the search of the model space, improving clustering performance by allowing cluster-specific numbers of factors, and uncertainty quantification.10Scopus© Citations 16 - PublicationA mixture of experts model for rank data with applications in election studiesA voting bloc is defined to be a group of voters who have similar voting preferences. The cleavage of the Irish electorate into voting blocs is of interest. Irish elections employ a 'single transferable vote' electoral system; under this system voters rank some or all of the electoral candidates in order of preference. These rank votes provide a rich source of preference information from which inferences about the composition of the electorate may be drawn. Additionally, the influence of social factors or covariates on the electorate composition is of interest. A mixture of experts model is a mixture model in which the model parameters are functions of covariates. A mixture of experts model for rank data is developed to provide a model-based method to cluster Irish voters into voting blocs, to examine the influence of social factors on this clustering and to examine the characteristic preferences of the voting blocs. The Benter model for rank data is employed as the family of component densities within the mixture of experts model; generalized linear model theory is employed to model the influence of covariates on the mixing proportions. Model fitting is achieved via a hybrid of the EM and MM algorithms. An example of the methodology is illustrated by examining an Irish presidential election. The existence of voting blocs in the electorate is established and it is determined that age and government satisfaction levels are important factors in influencing voting in this election.
337Scopus© Citations 82 - PublicationModel Based Clustering for Mixed Data: clustMDA model based clustering procedure for data of mixed type, clustMD, is developed using a latent variable model. It is proposed that a latent variable, following a mixture of Gaussian distributions, generates the observed data of mixed type. The observed data may be any combination of continuous, binary, ordinal or nominal variables. clustMD employs a parsimonious covariance structure for the latent variables, leading to a suite of six clustering models that vary in complexity and provide an elegant and unified approach to clustering mixed data. An expectation maximisation (EM) algorithm is used to estimate clustMD; in the presence of nominal data a Monte Carlo EM algorithm is required. The clustMD model is illustrated by clustering simulated mixed type data and prostate cancer patients, on whom mixed data have been recorded.
618Scopus© Citations 47