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Haarr, Marianne B.
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Haarr, Marianne B.
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- PublicationPreparation of iminosugars from aminopolyols via selective oxidation using galactose oxidase(Royal Society of Chemistry (RSC), 2022-11-07)
; ; ; Minimally protected aminopolyols are novel substrates for the galactose oxidase variant F2. Site-selective oxidation proceeds at the terminal primary alcohol, followed by spontaneous cyclisation to afford stable hemiaminal/hemiacetal anomers of the piperidine and azepane scaffolds, with isolated yields of up to 94%. Simultaneous deprotection and reduction occured readily to afford valuable and biologically relevant iminosugars.34Scopus© Citations 1