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Taday, Freya
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Taday, Freya
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Taday, Freya
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Combining bio- and organocatalysis for the synthesis of piperidine alkaloids
2022-02-07, Taday, Freya, Cairns, Ryan, O'Connell, Adam, O'Reilly, Elaine
There is continued interest in developing cascade processes for the synthesis of key chiral building blocks and bioactive natural products (or analogues). Here, we report a hybrid bio-organocatalytic cascade for the synthesis of a small panel of 2-substituted piperidines, relying on a transaminase to generate a key reactive intermediate for the complexity building Mannich reaction.