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Pes, Lara
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Pes, Lara
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Pes, Lara
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- PublicationSynthesis of a conformationally constrained delta-amino acid building block(Springer, 2013-02)
; ; ; ; Conformationally restricted amino acids are important components in peptidomimetics and drug design. Herein, we describe the synthesis of a novel, non-proteinogenic constrained delta amino acid containing a cyclobutane ring, cis-3(aminomethyl)cyclobutane carboxylic acid (ACCA). The synthesis of the target amino acid was achieved in seven steps, with the key reaction being a base induced intramolecular nucleophilic substitution. A small library of dipeptides was prepared through the coupling of ACCA with proteinogenic amino acids.Scopus© Citations 6 185