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Baumann, Marcus
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Baumann, Marcus
Official Name
Baumann, Marcus
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- PublicationSynthesis of Bioderived Cinnolines and Their Flow-Based Conversion into 1,4-Dihydrocinnoline DerivativesStarting from phenylhydrazine and glucose, a versatile cinnoline scaffold was obtained on a multigram scale and further derivatized. A simple continuous-flow hydrogenation process permits the conversion of selected cinnolines into their 1,4-dihydrocinnoline counterparts. These products are generated in high yields and high purities with residence times of less than one minute and, along with their cinnoline precursors, are expected to serve as valuable heterocyclic building blocks for future medicinal chemistry programs.
216Scopus© Citations 5 - PublicationA concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimicAn assembled suite of flow-based transformations have been used to rapidly scale-up the production of a novel auxin mimic-based herbicide which was required for preliminary field trials. The overall synthetic approach and optimisation studies are described along with a full description of the final reactor configurations employed for the synthesis as well as the downstream processing of the reaction streams.
126Scopus© Citations 17