Bioorganometallic Chemistry: A Key To New Chemotherapy?
12 June 2009
29T08:51:11Z April 2019
6-Substituted fulvenes are interesting and easily accessible starting materials for the synthesis of novel substituted titanocenes via reductive dimerisation, carbolithiation or hydridolithiation reactions, which are followed by a transmetallation reaction with titanium tetrachloride in the latter two cases. Depending on the substitution pattern, these titanocenes prove to be bioorganometallic anticancer drugs, which have significant potential against advanced or metastatic renal-cell cancer. Patients bearing these stages of kidney cancer have a poor prognosis so far and therefore real progress in the area of metal-based anticancer drugs may come from this simple and effective synthetic approach.
Higher Education Authority
University College Dublin
Centre for Synthesis and Chemical Biology (CSCB)
Central European Society for Anticancer Drug Research (CESAR)
Type of Material
Slovak University of Technology
Copyright (Published Version)
2009 Press of Slovak University of Technology, Bratislava
Status of Item
Melnik, M., Segl'a, P., Tatarko, M. (eds.). Insights into Coordination, Bioinorganic and Applied Inorganic Chemistry
The 22th International Conference on Coordination and Bioinorganic Chemistry, Smolenice, Slovakia, June 7 - 12, 2009
This item is made available under a Creative Commons License