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Noradrenergic genotype predicts lapses in sustained attention
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Date Issued
January 2009
Date Available
21T10:14:16Z January 2015
Abstract
Sustained attention is modulated by the neurotransmitter noradrenaline. The balance of dopamine and noradrenaline in the cortex is controlled by the DBH gene. The principal variant in this gene is a C/T change at position −1021, and the T allele at this locus is hypothesised to result in a slower rate of dopamine to noradrenaline conversion than the C allele. Two hundred participants who were genotyped for the DBH C−1021T marker performed the Sustained Attention to Response Task (SART). DBH genotype was found to significantly predict performance; participants with more copies of the T allele made more errors of commission, indicative of lapses in sustained attention. A significant negative correlation was also observed for all participants between errors of commission and mean reaction time. The decrease in noradrenaline occasioned by the T allele may impair sustained attention by reducing participants’ ability to remain alert throughout the task and by increasing their susceptibility to distractors.
Type of Material
Journal Article
Publisher
Elsevier
Journal
Neuropsychologia
Volume
47
Issue
2
Start Page
591
End Page
594
Copyright (Published Version)
2008 Elsevier
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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