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Liposomal gene delivery mediated by tissue-engineered scaffolds
Date Issued
January 2010
Date Available
28T15:15:09Z November 2013
Abstract
In the absence of any ideal gene delivery carrier despite the recent explosion of novel carrier systems, the current trend is to explore the complementary synergy promised by a combination of delivery systems such as liposomes, which are the most widely researched versatile non-viral carriers, and tissue-engineered scaffolds with macrostructures of defined architecture comprised of natural or synthetic macromolecules. Here, we discuss the recent advances in liposomal gene delivery and the possible benefits of a combined liposome–scaffold approach, such as long-term expression, enhanced stability, reduction in toxicity and ability to produce spatio-temporal expression patterns. This approach is generating significant impact in the field as a result of its potential for extended localised gene delivery for applications in a variety of clinical conditions.
Type of Material
Journal Article
Publisher
Elsevier
Journal
Trends in Biotechnology
Volume
28
Issue
1
Start Page
28
End Page
36
Copyright (Published Version)
2010 Elsevier
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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