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  5. Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex
 
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Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex

Author(s)
Keane, Páraic M.  
Poynton, Fergus E.  
Hall, James P.  
Quinn, Susan J.  
Uri
http://hdl.handle.net/10197/11605
Date Issued
2015-07-13
Date Available
2020-09-29T15:47:05Z
Abstract
Small changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo-oxidation by Λ-[Ru(TAP)2(dppz)]2+ have been compared in 5′-{CCGGATCCGG}2 and 5′-{CCGGTACCGG}2 using pico/nanosecond transient visible and time-resolved IR (TRIR) spectroscopy. The inefficiency of electron transfer in the TA sequence is consistent with the 5′-TA-3′ versus 5′-AT-3′ binding preference predicted by X-ray crystallography. The TRIR spectra also reveal the differences in binding sites in the two oligonucleotides.
Sponsorship
Irish Research Council
Science Foundation Ireland
Other Sponsorship
Royal Irish Academy/Royal Society International Exchange Scheme
UK Biotechnology and Biological Sciences Research Council
College of Science, UCD
UK Science and Technology Facilities Council
Type of Material
Journal Article
Publisher
Wiley
Journal
Angewandte Chemie - International Edition
Volume
54
Issue
29
Start Page
8364
End Page
8368
Copyright (Published Version)
2015 the Authors
Subjects

Ruthenium

Guanine

Phenazines

DNA

Intercalating agents

Crystallography, X-ra...

Base sequence

Base pairing

Oxidation-reduction

Light

Models, molecular

Coordination complexe...

DOI
10.1002/anie.201502608
Language
English
Status of Item
Peer reviewed
ISSN
1433-7851
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
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Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Com.pdf

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2.26 MB

Format

Adobe PDF

Checksum (MD5)

90216f61564585ab73e877ab8ed44cfe

Owning collection
Chemistry Research Collection

Item descriptive metadata is released under a CC-0 (public domain) license: https://creativecommons.org/public-domain/cc0/.
All other content is subject to copyright.

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