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Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex
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Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Com.pdf | 2.26 MB |
Date Issued
13 July 2015
Date Available
29T15:47:05Z September 2020
Abstract
Small changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo-oxidation by Λ-[Ru(TAP)2(dppz)]2+ have been compared in 5′-{CCGGATCCGG}2 and 5′-{CCGGTACCGG}2 using pico/nanosecond transient visible and time-resolved IR (TRIR) spectroscopy. The inefficiency of electron transfer in the TA sequence is consistent with the 5′-TA-3′ versus 5′-AT-3′ binding preference predicted by X-ray crystallography. The TRIR spectra also reveal the differences in binding sites in the two oligonucleotides.
Sponsorship
Irish Research Council
Science Foundation Ireland
Other Sponsorship
Royal Irish Academy/Royal Society International Exchange Scheme
UK Biotechnology and Biological Sciences Research Council
College of Science, UCD
UK Science and Technology Facilities Council
Type of Material
Journal Article
Publisher
Wiley
Journal
Angewandte Chemie - International Edition
Volume
54
Issue
29
Start Page
8364
End Page
8368
Copyright (Published Version)
2015 the Authors
Language
English
Status of Item
Peer reviewed
ISSN
1433-7851
This item is made available under a Creative Commons License
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Scopus© citations
29
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