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  5. Concentric Annular Liquid-Liquid Phase Separation for Flow Chemistry and Continuous Processing
 
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Concentric Annular Liquid-Liquid Phase Separation for Flow Chemistry and Continuous Processing

File(s)
FileDescriptionSizeFormat
Download Annular membrane phase separation_updated_Clean.docxArticle full text10.72 MB
Download Supporting information for TAPS additions_Updated.docxSupplementary material7.21 MB
Author(s)
Harding, Matthew J. 
Feng, Bin 
Lopez-Rodriguez, Rafael 
O'Connor, Heather 
Dowling, Denis P. 
Gibson, Geoff 
Girard, Kevin P. 
Ferguson, Steven 
Uri
http://hdl.handle.net/10197/12419
Date Issued
24 June 2021
Date Available
19T10:35:13Z August 2021
Abstract
A low-cost, modular, robust, and easily customisable continuous liquid-liquid phase separator has been developed that uses a tubular membrane and annular channels to allow high fluidic throughputs while maintaining rapid, surface wetting dominated, phase separation. The system is constructed from standard fluidic tube fittings and allows leak tight connections to be made without the need for adhesives, or O-rings. The units tested in this work have been shown to operate at flow rates of 0.1 – 300 mL/min, with equivalent residence times from 80 to 4 seconds, demonstrating the simplicity of scale-up with these units. Further scale-up to litre per minute scales of operation for single units and tens of litres/minute through limited numbering up should allow these low cost concentric annular tubular membrane separators to be used at continuous production scales for pharmaceutical applications for many solvent systems. In principle this approach may be sufficiently scalable to be utilized in-line, in batch pharmaceutical manufacturing also, through further scale-up and numbering up of units. Several solvent systems with varying interfacial tensions have been investigated, and the critical process parameters affecting successful separation have been identified. An additively manufactured diaphragm based back pressure regulator was also developed and printed in PEEK, allowing highly accurate, adjustable, and chemically compatible pressure control to be accessed at low cost.
Sponsorship
Enterprise Ireland
European Commission - European Regional Development Fund
Science Foundation Ireland
Type of Material
Journal Article
Publisher
Royal Society of Chemistry
Journal
Reaction Chemistry & Engineering
Volume
6
Issue
9
Start Page
1635
End Page
1643
Keywords
  • Pharmaceutical manufa...

  • Chemical manufacturin...

  • Phase separators

  • Surface tension

  • Fused filament fabric...

DOI
10.1039/D1RE00119A
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by/3.0/ie/
Owning collection
I-Form Research Collection
Scopus© citations
1
Acquisition Date
Jan 27, 2023
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Acquisition Date
Jan 28, 2023
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