Cold plasma deposition as a novel technology for cancer drug delivery

This thesis explores innovative treatments for glioblastoma multiforme (GBM), an aggressive brain cancer. It examines the potential of combining topotecan (TPT), a chemotherapeutic agent, with cold plasma therapy, which generates reactive species that can target cancer cells. Findings indicate that plasma activated water (PAW) significantly increases TPT's cytotoxicity in GBM cell lines, reducing cell viability and promoting apoptosis. Furthermore, plasma deposition improves TPT's stability and biological activity without altering its structure. The novel deposition protocol for TPT showed effective outcomes across GBM models and other cancer types, indicating potential for broader applications in oncology. This work suggests a promising avenue for localized GBM treatments, requiring further clinical investigation.