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Influence of molecular weight fractionation on the antimicrobial and anticancer properties of a fucoidan rich-extract from the macroalgae Fucus vesiculosus
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Cabral et al 2021.docx | 685.58 KB |
Date Issued
01 September 2021
Date Available
23T14:54:09Z September 2021
Abstract
The objective of this study was to investigate the antimicrobial and anticancer properties of a fucoidan extract and subsequent fractions isolated from the macroalgae Fucus vesiculosus. The fractions obtained (>300 kDa, <300 kDa, <100 kDa, <50 kDa and <10 kDa) could inhibit the growth of B. subtilis, E. coli, L. innocua and P. fluorescens when assayed at concentrations between 12,500 and 25,000 ppm. The bacterial growth was monitored by optical density (OD) measurements (600 nm, 24 h) at 30 °C or 37 °C, depending upon on the strain used. The extracted fractions were also tested for cytotoxicity against brain glioblastoma cancer cells using the Alamar Blue assay for 24 h, 48 h and 6 days. The >300 kDa fraction presented the lowest IC50 values (0.052% - 24 h; 0.032% - 6 days). The potential bioactivity of fucoidan as an antimicrobial and anticancer agent was demonstrated in this study. Hence, the related mechanisms of action should be explored in a near future.
Sponsorship
European Commission Horizon 2020
Science Foundation Ireland
Other Sponsorship
Spanish Ministry of Science, Innovation and Universities
Type of Material
Journal Article
Publisher
Elsevier
Journal
International Journal of Biological Macromolecules
Volume
186
Start Page
994
End Page
1002
Copyright (Published Version)
2021 the Authors
Language
English
Status of Item
Peer reviewed
ISSN
0141-8130
This item is made available under a Creative Commons License
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