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Cyclophilin function in Cancer; lessons from virus replication
Author(s)
Date Issued
2015-05
Date Available
2016-05-19T01:00:17Z
Abstract
Cyclophilins belong to a group of proteins that possess peptidyl prolyl isomerase activity and catalyse the cis-trans conversion of proline peptide bonds. Cyclophilin members play important roles in protein folding and as molecular chaperones, in addition to a well-established role as host factors required for completion of the virus life cycle. Members of the cyclophilin family are overexpressed in a range of human malignancies including hepatocellular cancer, pancreatic cancer, non-small cell lung cancer, gastric cancer, colorectal cancer and glioblastoma multiforme, however, their precise role in tumourigenesis remains unclear. In recent years, mounting evidence supports a role for prolyl isomerisation during mammalian cell division; a process with striking similarity to plasma membrane remodelling during virus replication. Here we will summarise our current understanding of the role of cyclophilins in cancer. We will review the function of cyclophilins during mammalian cell division and during HIV-1 infection, and highlight common processes involving members of the ESCRT and Rab GTPase families
Sponsorship
Science Foundation Ireland
Type of Material
Journal Article
Publisher
Bentham Science Publishers
Journal
Current Molecular Pharmacology
Volume
8
Subjects
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
File(s)
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Name
Cyclophilin function in Cancer_ lessons from virus replication gallery proof edits.pdf
Size
1.91 MB
Format
Adobe PDF
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