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Biotransformation of flurbiprofen by Cunninghamella species
Date Issued
2010-09
Date Available
2012-09-04T15:26:57Z
Abstract
The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated in Cunninghamella spp. Mono- and di-hydroxylated metabolites were detected using gas chromatography-mass spectrometry and fluorine-19 nuclear magnetic resonance spectroscopy, and the major metabolite 4’-hydroxyflurbiprofen was isolated by preparative HPLC. C. elegans DSM 1908 and C. blakesleeana DSM 1906 also produced a phase II (conjugated) metabolite, which was identified as the sulfated drug via deconjugation experiments.
Sponsorship
Other funder
Other Sponsorship
Environmental Protection Agency
Type of Material
Journal Article
Publisher
American Society for Microbiology
Journal
Applied and Environmental Microbiology
Volume
76
Issue
18
Start Page
6299
End Page
6303
Copyright (Published Version)
2010 American Society for Microbiology
Subjects
Subject – LCSH
Anti-inflammatory agents
Biotransformation (Metabolism)
Mucorales
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
File(s)
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Name
AEMTMP-02444-10_1.pdf
Size
172.99 KB
Format
Adobe PDF
Checksum (MD5)
2c2143e765ac1b0282423885e856e60b
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