Negative feedback is an ubiquitous feature of biological networks. Recent work from Sturm and colleaguespresents experimental evidence that biological negative feedback can serve the same function as it does for engineered systems: robustness to perturbations within the feedback loop. Such behavior has important implications for how to attack deregulated signaling networks containing negative feedback in diseases such as cancer.
SFI Grant No. 06/CE/B1129, and M.R.B. acknowledges a Marie Curie International Incoming Fellowship (236758) and an EMBO longterm fellowship (ALTF 815-2010).