Prevention of Neural Tube Defects in Ireland

Neural tube defects (NTDs) are a group of serious congenital malformations, including encephalocoele and spina bifida (SB) which are associated with failure of closure of the neural tube during early embryonic development. They affect approximately one in 1000 births globally, and constitute an important challenge in terms of mortality, morbidity, social and financial costs. Studies indicate that approximately two thirds, but not all, cases of NTDs are preventable. The burden of disease associated NTDs is higher in Ireland than in other countries.