Catching transcriptional regulation by thermostatistical modeling
07 August 2012
29T14:35:31Z November 2013
Gene expression is frequently regulated by multiple transcription factors (TFs). Thermostatistical methods allow for a quantitative description of interactions between TFs, RNA polymerase and DNA, and their impact on the transcription rates. We illustrate three different scales of the thermostatistical approach: the microscale of TF molecules, the mesoscale of promoter energy levels and the macroscale of transcriptionally active and inactive cells in a cell population. We demonstrate versatility of combinatorial transcriptional activation by exemplifying logic functions, such as AND and OR gates. We discuss a metric for cell-to-cell transcriptional activation variability known as Fermi entropy. Suitability of thermostatistical modeling is illustrated by describing the experimental data on transcriptional induction of NFκB and the c-Fos protein.
RIKEN Research Center for Allergy and Immunology W518, 1-7-22 Tsurumi-ku, Yokohama, 230-0045, Japan.
Type of Material
Copyright (Published Version)
2012 IOP Publishing
Status of Item
This item is made available under a Creative Commons License