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  5. Alternative Experimental Models of Ciliary Trafficking and Dysfunction in the Retina
 
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Alternative Experimental Models of Ciliary Trafficking and Dysfunction in the Retina

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Author(s)
Carter, Stephen P. 
Leyk, Janina 
Blacque, Oliver E. 
Kennedy, Breandán 
Uri
http://hdl.handle.net/10197/13215
Date Issued
2019
Date Available
21T08:38:46Z October 2022
Abstract
The cilia of cells constituent to the retina are fundamental to vision. Of the ∼250 genes causative of inherited retinal degeneration, 20% mediate functions related to photoreceptor primary cilium formation, structure or function. Primary cilia are sensory and signalling organelles emanating from the plasma membrane of most cells. They regulate a variety of biological processes, including left/right body axis asymmetry, limb patterning, central nervous system development and sensation. Cilia function by forming a specialised region of plasma membrane which concentrates specific signalling components, such as for sonic hedgehog signalling and phototransduction. Here, we review the roles of ciliary signalling and trafficking pathways in retinal biology and disease with a focus on the potential of non-rodent, metazoan experimental models for shedding light on these processes.
Sponsorship
European Commission Horizon 2020
Health Research Board
Irish Research Council
Type of Material
Book Chapter
Publisher
Royal Society of Chemistry
Keywords
  • Retinal biology

  • Inherited retinal deg...

  • Ciliopathies

  • Stem cell-derived ret...

  • Zebrafish

DOI
10.1039/9781788013666-00144
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Owning collection
Biomolecular and Biomedical Science Research Collection
Scopus© citations
0
Acquisition Date
Mar 27, 2023
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