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  5. Poly(ethylene glycol)-based backbones with high peptide loading capacities
 
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Poly(ethylene glycol)-based backbones with high peptide loading capacities

Author(s)
O'Connor, Aoife  
Marsat, Jean-Noël  
Mitrugno, Annachiara  
Brayden, David James  
et al.  
Uri
http://hdl.handle.net/10197/9665
Date Issued
2014-10-30
Date Available
2019-03-25T09:20:29Z
Abstract
Polymer-peptide conjugates are a promising class of compounds, where polymers can be used to overcome some of the limitations associated with peptides intended for therapeutic and/or diagnostic applications. Linear polymers such as poly(ethylene glycol) can be conjugated through terminal moieties and have therefore limited loading capacities. In this research, functionalised linear poly(ethylene glycol)s are utilised for peptide conjugation, to increase their potential loading capacities. These poly(ethylene glycol) derivatives are conjugated to peptide sequences containing representative side-chain functionalised amino acids, using different conjugation chemistries, including copper-catalysed azide-alkyne cycloaddition, amide coupling and thiol-ene reactions. Conjugation of a sequence containing the RGD motif to poly(allyl glycidyl ether) by the thiol-ene reaction, provided a conjugate which could be used in platelet adhesion studies.
Sponsorship
Health Research Board
Science Foundation Ireland
Type of Material
Journal Article
Publisher
MDPI
Journal
Molecules
Volume
19
Issue
11
Start Page
17559
End Page
17577
Copyright (Published Version)
2014 the Authors
Subjects

Blood platelets

Azides

Polyethylene glycols

Epoxy compounds

Alkynes

Sulfhydryl compounds

Amino acids

Peptide-polymer conju...

Loading capacity

Poly(allyl glycidyl e...

Thiol-ene conjugation...

DOI
10.3390/molecules191117559
Language
English
Status of Item
Peer reviewed
ISSN
1420-3049
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
File(s)
No Thumbnail Available
Name

molecules-19-17559 published.pdf

Size

382.13 KB

Format

Adobe PDF

Checksum (MD5)

4b3c1d214805976f7aa9be92f7433ae3

Owning collection
Veterinary Medicine Research Collection
Mapped collections
Conway Institute Research Collection

Item descriptive metadata is released under a CC-0 (public domain) license: https://creativecommons.org/public-domain/cc0/.
All other content is subject to copyright.

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