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  5. Poly(ethylene glycol)-based backbones with high peptide loading capacities
 
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Poly(ethylene glycol)-based backbones with high peptide loading capacities

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Author(s)
O'Connor, Aoife 
Marsat, Jean-Noël 
Mitrugno, Annachiara 
Brayden, David James 
et al. 
Uri
http://hdl.handle.net/10197/9665
Date Issued
30 October 2014
Date Available
25T09:20:29Z March 2019
Abstract
Polymer-peptide conjugates are a promising class of compounds, where polymers can be used to overcome some of the limitations associated with peptides intended for therapeutic and/or diagnostic applications. Linear polymers such as poly(ethylene glycol) can be conjugated through terminal moieties and have therefore limited loading capacities. In this research, functionalised linear poly(ethylene glycol)s are utilised for peptide conjugation, to increase their potential loading capacities. These poly(ethylene glycol) derivatives are conjugated to peptide sequences containing representative side-chain functionalised amino acids, using different conjugation chemistries, including copper-catalysed azide-alkyne cycloaddition, amide coupling and thiol-ene reactions. Conjugation of a sequence containing the RGD motif to poly(allyl glycidyl ether) by the thiol-ene reaction, provided a conjugate which could be used in platelet adhesion studies.
Sponsorship
Health Research Board
Science Foundation Ireland
Type of Material
Journal Article
Publisher
MDPI
Journal
Molecules
Volume
19
Issue
11
Start Page
17559
End Page
17577
Copyright (Published Version)
2014 the Authors
Keywords
  • Blood platelets

  • Azides

  • Polyethylene glycols

  • Epoxy compounds

  • Alkynes

  • Sulfhydryl compounds

  • Amino acids

  • Peptide-polymer conju...

  • Loading capacity

  • Poly(allyl glycidyl e...

  • Thiol-ene conjugation...

DOI
10.3390/molecules191117559
Language
English
Status of Item
Peer reviewed
ISSN
1420-3049
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Owning collection
Veterinary Medicine Research Collection
Scopus© citations
8
Acquisition Date
Mar 27, 2023
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