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  5. Classifying Individuals Into a Dietary Pattern Based on Metabolomic Data
 
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Classifying Individuals Into a Dietary Pattern Based on Metabolomic Data

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Download Prendiville et al 2021, final.pdf754.65 KB
Author(s)
Prendiville, Orla 
Walton, Janette 
Flynn, Albert 
Nugent, Anne P. 
McNulty, Breige A. 
Brennan, Lorraine 
Uri
http://hdl.handle.net/10197/13016
Date Issued
June 2021
Date Available
25T15:47:04Z July 2022
Abstract
Scope: The objectives are to develop a metabolomic-based model capable of classifying individuals into dietary patterns and to investigate the reproducibility of the model. Methods and Results: K-means cluster analysis is employed to derive dietary patterns using metabolomic data. Differences across the dietary patterns are examined using nutrient biomarkers. The model is used to assign individuals to a dietary pattern in an independent cohort, A-DIET Confirm (n = 175) at four time points. The stability of participants to a dietary pattern is assessed. Four dietary patterns are derived: moderately unhealthy, convenience, moderately healthy, and prudent. The moderately unhealthy and convenience patterns has lower adherence to the alternative healthy eating index (AHEI) and the alternative mediterranean diet score (AMDS) compared to the moderately healthy and prudent patterns (AHEI = 24.5 and 22.9 vs 26.7 and 28.4, p < 0.001). The dietary patterns are replicated in A-DIET Confirm, with good reproducibility across four time points. The stability of participants’ dietary pattern membership ranged from 25.0% to 61.5%. Conclusion: The multivariate model classifies individuals into dietary patterns based on metabolomic data. In an independent cohort, the model classifies individuals into dietary patterns at multiple time points furthering the potential of such an approach for nutrition research.
Sponsorship
European Research Council
Type of Material
Journal Article
Publisher
Wiley
Journal
Molecular Nutrition and Food Research
Volume
65
Issue
11
Copyright (Published Version)
2021 the Authors
Keywords
  • Biomarkers

  • Dietary patterns

  • Metabolomics

  • Reproducibility

DOI
10.1002/mnfr.202001183
Language
English
Status of Item
Peer reviewed
ISSN
1613-4125
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Owning collection
Agriculture and Food Science Research Collection
Scopus© citations
7
Acquisition Date
Mar 20, 2023
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