Prediction of Large for Gestational Age Infants in Overweight and Obese Women at Approximately 20 Gestational Weeks

Large for gestational age (LGA) births are associated with many maternal and perinatal complications. As overweight and obesity are risk factors for LGA, we aimed to predict LGA in overweight and obese women at approximately 20 gestational weeks, so that we can identify women at risk of LGA early to allow for appropriate interventions. A random forest algorithm was applied to maternal characteristics and blood biomarkers at baseline and 20 gestational weeks' ultrasound scan findings to develop a prediction model. Here we present our preliminary results demonstrating potential for use in clinical decision support for identifying patients early in pregnancy at risk of an LGA birth.