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Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration
Date Issued
2018-05-03
Date Available
2020-09-22T14:58:04Z
Abstract
This review discusses the therapeutic potential of brain-derived neurotrophic factor (BDNF) for retinal degeneration. BDNF, nerve growth factor (NGF), neurotrophin 3 (NT-3) and NT-4/NT-5 belong to the neurotrophin family. These neuronal modulators activate a common receptor and a specific tropomyosin-related kinase (Trk) receptor. BDNF was identified as a photoreceptor protectant in models of retinal degeneration as early as 1992. However, development of effective therapeutics that exploit this pathway has been difficult due to challenges in sustaining therapeutic levels in the retina.
Sponsorship
Health Research Board
Type of Material
Book Chapter
Publisher
Springer
Series
Advances in Experimental Medicine and Biology
1074
Copyright (Published Version)
2018 Springer Nature
Language
English
Status of Item
Peer reviewed
Journal
Ash, J.D., Anderson, R.E., LaVail, M.M., Bowes Rickman, C., Hollyfield, J.G, Grimm, C. Retinal Degenerative Diseases: Mechanisms and Experimental Therapy
ISBN
978-3-319-75401-7
This item is made available under a Creative Commons License
File(s)
No Thumbnail Available
Name
XX.Daly (1).docx
Size
92.46 KB
Format
Microsoft Word
Checksum (MD5)
5bac35ba1634382c6bd409a574b47b71
Owning collection
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