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  5. Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity
 
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Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity

Author(s)
Barros, Caio H. N.  
Hiebner, Dishon W.  
Fulaz, Stephanie  
Vitale, Stefania  
Quinn, Laura  
Casey, Eoin  
Uri
http://hdl.handle.net/10197/28310
Date Issued
2021-04-13
Date Available
2025-06-17T13:20:33Z
Abstract
Background: The ubiquitous nature of bacterial biofilms combined with the enhanced resistance towards antimicrobials has led to the development of an increasing number of strategies for biofilm eradication. Such strategies must take into account the existence of extracellular polymeric substances, which obstruct the diffusion of antibiofilm agents and assists in the maintenance of a well-defended microbial community. Within this context, nanoparticles have been studied for their drug delivery efficacy and easily customised surface. Nevertheless, there usually is a requirement for nanocarriers to be used in association with an antimicrobial agent; the intrinsically antimicrobial nanoparticles are most often made of metals or metal oxides, which is not ideal from ecological and biomedical perspectives. Based on this, the use of polymeric micelles as nanocarriers is appealing as they can be easily prepared using biodegradable organic materials. Results: In the present work, micelles comprised of poly(lactic-co-glycolic acid) and dextran are prepared and then functionalised with curcumin. The effect of the functionalisation in the micelle’s physical properties was elucidated, and the antibacterial and antibiofilm activities were assessed for the prepared polymeric nanoparticles against Pseudomonas spp. cells and biofilms. It was found that the nanoparticles have good penetration into the biofilms, which resulted in enhanced antibacterial activity of the conjugated micelles when compared to free curcumin. Furthermore, the curcumin-functionalised micelles were efficient at disrupting mature biofilms and demonstrated antibacterial activity towards biofilm-embedded cells. Conclusion: Curcumin-functionalised poly(lactic-co-glycolic acid)-dextran micelles are novel nanostructures with an intrinsic antibacterial activity tested against two Pseudomonas spp. strains that have the potential to be further exploited to deliver a secondary bioactive molecule within its core. Graphic Abstract: [Figure not available: see fulltext.]
Sponsorship
Science Foundation Ireland
Type of Material
Journal Article
Publisher
Springer Science and Business Media LLC
Journal
Journal of Nanobiotechnology
Volume
19
Issue
1
Copyright (Published Version)
2021 the Authors
Subjects

Biofilms

Curcumin

Polymers

Dextrans

Micelles

Nanoparticles

DOI
10.1186/s12951-021-00851-2
Language
English
Status of Item
Peer reviewed
ISSN
1477-3155
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by/3.0/ie/
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curcumin-modified amphiphilic polymeric micelles with antibacterial activity.pdf

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4.95 MB

Format

Adobe PDF

Checksum (MD5)

f15479f2df49f9f1841b489c17880864

Owning collection
Chemical and Bioprocess Engineering Research Collection
Mapped collections
UCD Biofilm Engineering Lab Research Collection

Item descriptive metadata is released under a CC-0 (public domain) license: https://creativecommons.org/public-domain/cc0/.
All other content is subject to copyright.

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