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Signalling by protein phosphatases and drug development: a systems-centred view
Date Issued
2012-03-14
Date Available
2014-05-02T08:45:24Z
Abstract
Protein modification cycles catalysed by opposing enzymes, such as kinases and phosphatases, form the backbone of signalling networks. Although, historically, kinases have been at the research forefront, a systems-centred approach reveals predominant roles for phosphatases in controlling the network response times and spatio-temporal profiles of signalling activities. Emerging evidence suggests that phosphatase kinetics are critical for network function and cell-fate decisions. Protein phosphatases operate as both immediate and delayed regulators of signal transduction, capable of attenuating or amplifying signalling. This versatility of phosphatase action emphasizes the need for systems biology approaches to understand cellular signalling networks and predict the cellular outcomes of combinatorial drug interventions.
Other Sponsorship
SFI & NIH
Type of Material
Journal Article
Publisher
Wiley Blackwell (Blackwell Publishing)
Journal
FEBS Journal
Volume
280
Issue
2
Start Page
751
End Page
765
Copyright (Published Version)
2012 Wiley Blackwell (Blackwell Publishing)
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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