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  5. Advances in Affinity Ligand-Functionalized Nanomaterials for Biomagnetic Separation
 
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Advances in Affinity Ligand-Functionalized Nanomaterials for Biomagnetic Separation

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Author(s)
Fields, Conor 
Li, Peng 
O'Mahony, James J. 
Lee, Gil U. 
Uri
http://hdl.handle.net/10197/8379
Date Issued
January 2016
Date Available
28T13:18:47Z February 2017
Abstract
The downstream processing of proteins remains the most significant cost in protein production, and is largely attributed to rigorous chromatographic purification protocols, where the stringency of purity for biopharmaceutical products sometimes exceeds 99%. With an ever burgeoning biotechnology market, there is a constant demand for alternative purification methodologies, to ameliorate the dependence on chromatography, while still adhering to regulatory concerns over product purity and safety. In this article, we present an up-to-date view of bioseparation, with emphasis on magnetic separation and its potential application in the field. Additionally, we discuss the economic and performance benefits of synthetic ligands, in the form of peptides and miniaturized antibody fragments, compared to full-length antibodies. We propose that adoption of synthetic affinity ligands coupled with magnetic adsorbents, will play an important role in enabling sustainable bioprocessing in the future.
Sponsorship
Science Foundation Ireland
Type of Material
Journal Article
Publisher
Wiley
Journal
Biotechnology and Bioengineering
Volume
113
Issue
1
Start Page
11
End Page
25
Copyright (Published Version)
2015 Wiley
Keywords
  • Antibody fragments

  • Bioseparation

  • Micro-particles

  • Nanoparticles

  • Peptides

  • Superparamagnetic

DOI
10.1002/bit.25665
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Owning collection
Medicine Research Collection
Scopus© citations
31
Acquisition Date
Mar 24, 2023
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