CycloPs : generating virtual libraries of cyclized and constrained peptides including nonnatural amino acids

We introduce CycloPs, software for the generation of virtual libraries of
constrained peptides including natural and nonnatural commercially available amino acids.
The software is written in the cross-platform Python programming language, and features include
generating virtual libraries in one-dimensional SMILES and three-dimensional SDF formats,
suitable for virtual screening. The stand-alone software is capable of filtering the virtual libraries
using empirical measurements, including peptide synthesizability by standard peptide synthesis
techniques, stability, and the druglike properties of the peptide. The software and accompanying
Web interface is designed to enable the rapid generation of large, structurally diverse,
synthesizable virtual libraries of constrained peptides quickly and conveniently, for use in virtual
screening experiments. The stand-alone software, and the Web interface for evaluating these empirical properties of a single peptide,
are available at http://bioware.ucd.ie.