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  5. Subjective taste and smell changes in treatment-naïve people with solid tumours
 
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Subjective taste and smell changes in treatment-naïve people with solid tumours

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Download Taste_and_Smell_FINAL_DRAFT.doc439 KB
Author(s)
Spotten, L. E. 
Corish, Clare A. 
Lorton, C. M. 
O'Connor, B. 
Walsh, Declan 
et al. 
Uri
http://hdl.handle.net/10197/9386
Date Issued
July 2016
Date Available
17T16:06:36Z May 2018
Abstract
Purpose: Taste and smell changes (TSCs) have been studied in cancer post-chemotherapy (CT) or radiotherapy (RT), and in head and neck (H&N) tumours. They may present as part of a symptom cluster with anorexia, early satiety and weight loss, which can negatively impact nutritional status. This study aimed to examine the prevalence, severity and characteristics of TSCs and their relationship with co-occurring symptoms in non-H&N solid tumours before CT or RT. Methods: A prospective observational study was conducted. Forty consecutive pre-treatment cancer patients who attended oncology outpatients over six weeks were recruited. Data on TSCs, symptoms and nutritional status were obtained using the ‘Taste and Smell Survey’ and the ‘abridged Patient-Generated Subjective Global Assessment’ (abPG-SGA). Weight and height were measured, and BMI calculated. SPSS® was used for statistical analysis. Two-sided P values <0.05 were considered statistically significant. Results: Most patients were newly diagnosed (70%; n=28). Nineteen (48%) reported TSCs; 9 noted stronger sweet taste and 7 stronger salt taste. Of these, 4 reported stronger and 4 weaker odour sensation. Those deemed at nutritional risk by the abPG-SGA tended to have more TSCs. TSCs were significantly associated with dry mouth (P<0.01), early satiety (P<0.05) and fatigue (P<0.05). Conclusions: TSCs preceded CT or RT in almost half of treatment-naive patients with solid tumours, notably stronger sweet and salt tastes. Most of those at nutritional risk reported TSCs. TSCs were significantly associated with other symptoms. Future research and clinical guidelines with a common terminology for assessment, diagnosis and management of cancer TSCs are needed.
Type of Material
Journal Article
Publisher
Springer
Journal
Supportive Care in Cancer
Volume
24
Issue
7
Start Page
3201
End Page
3208
Copyright (Published Version)
2016 Springer
Keywords
  • Cancer

  • Nutrition

  • Radiation therapy

  • Smell

  • Taste

DOI
10.1007/s00520-016-3133-2.
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Owning collection
Public Health, Physiotherapy and Sports Science Research Collection
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