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Imatinib-dependent tyrosine phosphorylation profiling of Bcr-Abl-positive chronic myeloid leukemia cells
Author(s)
Date Issued
2012-08-27
Date Available
2013-11-29T10:20:36Z
Abstract
Bcr-Abl is the major cause and pathogenetic principle of chronic myeloid leukemia (CML). Bcr-Abl results from a chromosomal translocation that fuses the bcr and abl genes, thereby generating a constitutively active tyrosine kinase, which stimulates several signaling networks required for proliferation and survival.
Other Sponsorship
Fondation Leducq: the Alliance for CamKII signaling in heart 128 disease (CP, AS, AJRH), and the Netherlands Proteomics Centre, embedded in the 129 Netherlands Genomics Initiative, (CP, AS, AJRH) and Science Foundation Ireland under 130 Grant No. 06/CE/B1129
Type of Material
Journal Article
Publisher
Nature Publishing Group
Journal
Leukemia
Volume
27
Issue
3
Start Page
743
End Page
746
Copyright (Published Version)
2012 Nature Publishing Group
Subjects
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
File(s)
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Name
Paper61.pdf
Size
905.63 KB
Format
Adobe PDF
Checksum (MD5)
db0ea32feb612124ba744865971e3ada
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