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  5. One-step diketopiperazine synthesis using phase transfer catalysis
 
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One-step diketopiperazine synthesis using phase transfer catalysis

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Download O'Reilly Tet Lett 2009.doc305 KB
Author(s)
O'Reilly, Elaine 
Lestini, Elena 
Balducci, Daniele 
Paradisi, Francesca 
Uri
http://hdl.handle.net/10197/3638
Date Issued
15 April 2009
Date Available
13T15:25:46Z June 2012
Abstract
A simple and efficient one-step procedure is described for the synthesis of a number of symmetrical 1,4-disubstituted piperazine-2,5-diones under phase transfer conditions. The reactions are carried out at room temperature, starting from a suitable N-chloroacetamide in the presence of an aqueous solution of sodium hydroxide. Piperazine-2,5-diones were obtained with excellent selectivity in yields of up to 90%.
Sponsorship
Higher Education Authority
Irish Research Council for Science, Engineering and Technology
Type of Material
Journal Article
Publisher
Elsevier
Journal
Tetrahedron Letters
Volume
50
Issue
15
Start Page
1748
End Page
1750
Copyright (Published Version)
2009 Elsevier
Keywords
  • Diketopiperazine

  • Chloroacetamide

  • Phase transfer cataly...

  • TEBA

Subject – LCSH
Organic cyclic compounds--Synthesis
Phase-transfer catalysts
DOI
10.1016/j.tetlet.2009.01.146
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-sa/1.0/
Owning collection
Chemistry Research Collection
Scopus© citations
22
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Jan 30, 2023
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