Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling
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|Title:||Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling||Authors:||Hennigan, Kerrie
Conroy, Paul J.
|Permanent link:||http://hdl.handle.net/10197/10064||Date:||Oct-2016||Online since:||2019-04-23T08:49:37Z||Abstract:||Eosinophils account for 1–3% of peripheral blood leukocytes and accumulate at sites of allergic inflammation, where they play a pathogenic role. Studies have shown that treatment with mepolizumab (an anti-IL-5 monoclonal antibody) is beneficial to patients with severe eosinophilic asthma, however, the mechanism of precisely how eosinophils mediate these pathogenic effects is uncertain. Eosinophils contain several cationic granule proteins, including Eosinophil Peroxidase (EPO). The main significance of this work is the discovery of EPO as a novel ligand for the HER2 receptor. Following HER2 activation, EPO induces activation of FAK and subsequent activation of β1-integrin, via inside-out signaling. This complex results in downstream activation of ERK1/2 and a sustained up regulation of both MUC4 and the HER2 receptor. These data identify a receptor for one of the eosinophil granule proteins and demonstrate a potential explanation of the proliferative effects of eosinophils.||Funding Details:||Health Research Board||Type of material:||Journal Article||Publisher:||Elsevier||Journal:||Clinical Immunology||Volume:||171||Start page:||1||End page:||11||Copyright (published version):||2016 the Authors||Keywords:||Cell line; Humans; Eosinophil perioxidase; Extracellular Signal-Regulated MAP Kinases; Receptor; erbB-2; Antigens; CD29; Recombinant proteins; RNA; Small interfering; Signal transduction; Focal adhesion kinase 1; Mucin-4||DOI:||10.1016/j.clim.2016.08.009||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Computer Science Research Collection|
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